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Spermidine: Difference between revisions
→Spermidine and Longevity
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Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice.<ref>https://genomics.senescence.info/drugs/browse.php?search_term=spermidine</ref> The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy.{{#pmid:27841876|pmid27841876}} | Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice.<ref>https://genomics.senescence.info/drugs/browse.php?search_term=spermidine</ref> The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy.{{#pmid:27841876|pmid27841876}} | ||
However, the Interventions Testing Program | The [[Interventions Testing Program (ITP)]] gave mice spermidine for 6 month. However, no increase in spermidine or spermin levels was observed in the blood, liver, or other tissues. The lack of change in spermidine levels led to the decision not to proceed with further lifespan testing in mice.<ref>[[2022-04-12 - Dr. Richard Miller - Longevity Supplements - Interventions Testing Program Results]]</ref> | ||
could not find any increase in spermidine or spermine levels in any tissues of mice and therefore did not consider it for a lifespan test. | |||
=== Autophagy === | === Autophagy === | ||