Spermidine: Difference between revisions

Line 65: Line 65:
Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice.<ref>https://genomics.senescence.info/drugs/browse.php?search_term=spermidine</ref> The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy.{{#pmid:27841876|pmid27841876}}
Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice.<ref>https://genomics.senescence.info/drugs/browse.php?search_term=spermidine</ref> The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy.{{#pmid:27841876|pmid27841876}}


The [[Interventions Testing Program (ITP)]] gave mice spermidine for 6 month. However, no increase in spermidine or spermin levels was observed in the blood, liver, or other tissues. The lack of change in spermidine levels led to the decision not to proceed with further lifespan testing in mice.<ref>[[2022-04-12 - Dr. Richard Miller - Longevity Supplements - Interventions Testing Program Results]]</ref>
The [[Interventions Testing Program (ITP)]] gave mice spermidine for 6 month. However, no increase in spermidine or spermine levels was observed in the blood, liver, or other tissues. The lack of change in spermidine levels led to the decision not to proceed with further lifespan testing in mice.<ref>[[2022-04-12 - Dr. Richard Miller - Longevity Supplements - Interventions Testing Program Results]]</ref>


=== Autophagy ===
=== Autophagy ===