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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 14:46, 21 November 2023
, 21 November 2023→Side Effects
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Overall, there have been no serious side effects in humans clinical trials that have been due to the use of NMN. When taken at higher doses than intended, you could be facing side effects such as nausea, diarrhea, indigestion, and stomach discomfort. However, these are common side effects of supplements when taken in amounts that are too high.<ref>https://www.dremilnutrition.com/post/will-i-get-side-effects-from-my-nmn-intake#:~:text=Potential%20NMN%20Side%20Effects%20%2B%20Other%20Safety%20Concerns&text=When%20taken%20at%20higher%20doses,amounts%20that%20are%20too%20high.</ref> | Overall, there have been no serious side effects in humans clinical trials that have been due to the use of NMN. When taken at higher doses than intended, you could be facing side effects such as nausea, diarrhea, indigestion, and stomach discomfort. However, these are common side effects of supplements when taken in amounts that are too high.<ref>https://www.dremilnutrition.com/post/will-i-get-side-effects-from-my-nmn-intake#:~:text=Potential%20NMN%20Side%20Effects%20%2B%20Other%20Safety%20Concerns&text=When%20taken%20at%20higher%20doses,amounts%20that%20are%20too%20high.</ref> | ||
Some individuals reported in NMN forums '''low energy''' and '''tiredness''' potentially caused by [[Methyl Donor Deficiency|methyl donor deficiency]].<ref name=":0">https://renuebyscience.com/forums/viewtopic.php?t=2575</ref> It is important to monitor for any adverse reactions, especially when starting supplementation or changing dosages. | Some individuals reported in NMN forums '''low energy''' and '''tiredness''' potentially caused by [[Methyl Donor Deficiency|methyl donor deficiency]] (see next section).<ref name=":0">https://renuebyscience.com/forums/viewtopic.php?t=2575</ref> The side effects can occur from the beginning or after a longer period of use. | ||
It is important to monitor for any adverse reactions, especially when starting supplementation or changing dosages. | |||
===[[Methyl Donor Deficiency]]=== | ===[[Methyl Donor Deficiency]]=== | ||
There is a theoretical concern that consuming NMN could deplete [[Methyl Donors|methyl groups]] in the body and might lead to a [[Methyl Donor Deficiency]] associated with symptoms such as low energy and tiredness. NMN is converted to NAD+ in the body, which can then be broken down into nicotinamide. Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which is excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body. | There is a theoretical concern that consuming NMN could deplete [[Methyl Donors|methyl groups]] in the body and might lead to a [[Methyl Donor Deficiency]] associated with symptoms such as low energy and tiredness. NMN is converted to NAD+ in the body, which can then be broken down into nicotinamide. Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which is excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body. | ||