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Isoleucine: Difference between revisions
→Isoleucine and Longevity
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|}All these foods contain almost exclusively chemically bound <small>L</small>-Isoleucine as a protein component, but in their raw state, they contain no free <small>L</small>-Isoleucine. | |}All these foods contain almost exclusively chemically bound <small>L</small>-Isoleucine as a protein component, but in their raw state, they contain no free <small>L</small>-Isoleucine. | ||
== Isoleucine and Longevity == | == Isoleucine and Longevity == | ||
Recent studies have shown that isoleucine plays a significant role in the aging process, particularly in the context of metabolic health and lifespan extension. | |||
=== Insulin Resistance === | === Insulin Resistance === | ||
Isoleucine, like other branched-chain amino acids, is associated with insulin resistance: higher levels of isoleucine are observed in the blood of diabetic mice, rats, and humans.{{pmid|25287287}} In diet-induced obese and insulin resistant mice, a diet with decreased levels of isoleucine (with or without the other branched-chain amino acids) results in reduced adiposity and improved insulin sensitivity.{{pmid|29266268}}{{pmid|33887198}} Reduced dietary levels of isoleucine are required for the beneficial metabolic effects of a low protein diet.{{pmid|33887198}} In humans, a protein restricted diet lowers blood levels of isoleucine and decreases fasting blood glucose levels.{{pmid|27346343 | Isoleucine, like other branched-chain amino acids, is associated with insulin resistance: higher levels of isoleucine are observed in the blood of diabetic mice, rats, and humans.{{pmid|25287287}} In diet-induced obese and insulin resistant mice, a diet with decreased levels of isoleucine (with or without the other branched-chain amino acids) results in reduced adiposity and improved insulin sensitivity.{{pmid|29266268}}{{pmid|33887198}} Reduced dietary levels of isoleucine are required for the beneficial metabolic effects of a low protein diet.{{pmid|33887198}} In humans, a protein restricted diet lowers blood levels of isoleucine and decreases fasting blood glucose levels.{{pmid|27346343}} In humans, higher dietary levels of isoleucine are associated with greater body mass index.{{pmid|33887198}} | ||
=== Isoleucine Restriction === | |||
Isoleucine restriction (IleR) has been identified as a significant factor in improving metabolic health and extending lifespan, particularly in genetically heterogeneous UM-HET3 mice. Restricting dietary isoleucine promotes leanness and glycemic control in both sexes, while also reprogramming hepatic metabolism in a sex-specific manner. Notably, IleR has been observed to reduce frailty and increase the lifespan by 33% of both male and female mice, with more pronounced effects in males. These findings suggest that IleR, or pharmaceuticals that mimic its effects, might serve as a geroprotective intervention, offering potential benefits for healthspan and longevity. The research underscores the importance of isoleucine in diet and aging, and its potential as a target for nutritional and pharmacological interventions in the field of gerontology.{{pmid|37939658}} | |||
== See Also == | == See Also == | ||