Nicotinamide Mononucleotide (NMN): Difference between revisions

Nicotinamide Mononucleotide (NMN) (view source)

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 === Dephosphorylation to NR as a Precursor ===
-An alternative and currently more widely accepted theory proposes that NMN is not directly utilized by cells. Instead, it is first converted to '''Nicotinamide Riboside (NR)''' through dephosphorylation before cellular absorption. This conversion is mediated by enzymes like CD73. Once inside the cell as NR, it is then phosphorylated into NMN{{pmid|27725675}}{{pmid|32389638}}. Studies, such as those by Kim et al., indicate that orally ingested NMN is predominantly converted to NR in the intestinal tissue before absorption, challenging the view of NMN as a direct precursor to NAD+{{pmid|37463842}}.
+An alternative and currently more widely accepted theory proposes that NMN is not directly utilized by cells. Instead, it is first converted to '''Nicotinamide Riboside (NR)''' through dephosphorylation before cellular absorption. This conversion is mediated by enzymes like CD73. Once inside the cell as NR, it is then phosphorylated into NMN{{pmid|27725675}}{{pmid|32389638}}.
+While direct transportation into the cell and dephosphorylation to NR can coexists, studies indicate that orally ingested NMN is predominantly converted to NR in the intestinal tissue before absorption, challenging the view of NMN as a direct precursor to NAD+{{pmid|37463842}}.
 ==Potential Benefits==