Caloric Restriction: Difference between revisions

Caloric Restriction (view source)

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-Caloric restriction (CR), a dietary regimen that reduces calorie intake without incurring malnutrition, has been a subject of scientific study in the context of aging and longevity. This practice is thought to extend lifespan and improve health outcomes in various species, including potentially humans.
+'''Calorie Restriction''' (CR), also known as '''calorie restriction''' or '''dietary restriction''', refers to a [[diet]] that reduces the intake of chemically bound [[energy]] from [[food]]s by 10 to 50 percent compared to ''[[ad libitum]]'' ("at will") [[nutrition]]. The goal is to achieve a higher [[life expectancy]] or at least delayed [[aging]] or health-promoting effects{{pmid|21663754}}{{pmid|19104499}}, without leading to [[malnutrition]].
+In a number of [[model organism|model organisms]], a health-promoting and life-extending effect has been demonstrated through this method. However, no extension of life expectancy has been observed in some species or [[breed (breeding)|breeds]]. The extension of life expectancy in some rodent strains by up to 50%{{pmid|21840335}} is dependent on the [[genome]] and sex among other factors{{pmid|25269675}}.
 ==Effects in Model Organisms==
 === Positive Effects ===
 [[File:Caloric restriction 02.png|thumb|Effects of calorie restriction on the survival rate of laboratory mice (CR=Calorie Restriction).{{pmid|3958810}}]]