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Xenohormesis: Difference between revisions
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'''Xenohormesis''' is a hypothesis that posits that certain molecules such as plant polyphenols, which indicate stress in the plants, can have benefits of another organism (heterotrophs) which consumes it. Or in simpler terms, xenohormesis is interspecies hormesis. The expected benefits include improve lifespan and fitness, by activating the animal's cellular stress response.{{pmid|18455976}} | '''Xenohormesis''' is a hypothesis that posits that certain molecules such as plant polyphenols, which indicate stress in the plants, can have benefits of another organism (heterotrophs) which consumes it. Or in simpler terms, xenohormesis is interspecies hormesis. The expected benefits include improve lifespan and fitness, by activating the animal's cellular stress response.{{pmid|18455976}} | ||
The term xenohormesis was first coined by Kondrad T. Howitz and [[David A. Sinclair]], in the 2004 paper "Small molecules that regulate lifespan: evidence for xenohormesis".<ref>{{cite journal|last1=Lamming|journal=Molecular Microbiology|s2cid=18803431|pmid=15306006|doi=10.1111/j.1365-2958.2004.04209.x|pages=1003–1009|issue=4|volume=53|url=https://semanticscholar.org/paper/df2808b38be6a75089b01b46b19920b455229a04|first1=Dudley W.|title=Small molecules that regulate lifespan: evidence for xenohormesis|date=16 July 2004|first3=David A.|last3=Sinclair|first2=Jason G.|last2=Wood|doi-access=free}}</ref> ''Xeno'' comes from greek, meaning foreign, and hormesis is the adaptive response of organisms and cells to stress. | The term xenohormesis was first coined by Kondrad T. Howitz and [[David A. Sinclair]], in the 2004 paper "Small molecules that regulate lifespan: evidence for xenohormesis".<ref>{{cite journal|last1=Lamming|journal=Molecular Microbiology|s2cid=18803431|pmid=15306006|doi=10.1111/j.1365-2958.2004.04209.x|pages=1003–1009|issue=4|volume=53|url=https://semanticscholar.org/paper/df2808b38be6a75089b01b46b19920b455229a04|first1=Dudley W.|title=Small molecules that regulate lifespan: evidence for xenohormesis|date=16 July 2004|first3=David A.|last3=Sinclair|first2=Jason G.|last2=Wood|doi-access=free}}</ref> ''Xeno'' comes from greek, meaning foreign, and hormesis is the adaptive response of organisms and cells to stress.{{pmid|18455976}} | ||
This may be useful to evolve, as it gives possible cues about the state of the environment. If the plants an animal is eating have increased polyphenol content, it means the plant is under stress and may signal famines. Using the chemical cues the heterotophs could preemptively prepare and defend itself before conditions worsen. A possible example may be [[Resveratrol|resveratrol]], which is famously found in red wine, which modulates over two dozen receptors and enzymes in mammals. | This may be useful to evolve, as it gives possible cues about the state of the environment. If the plants an animal is eating have increased polyphenol content, it means the plant is under stress and may signal famines. Using the chemical cues the heterotophs could preemptively prepare and defend itself before conditions worsen. A possible example may be [[Resveratrol|resveratrol]], which is famously found in red wine, which modulates over two dozen receptors and enzymes in mammals.{{pmid|18455976}} | ||
Xenohormesis could also explain several phenomena seen in the ethno-pharmaceutical (traditional medicine) side of things. Such as in the case of cinnamon, which in several studies have shown to help treat type 2 diabetes, but hasn't been confirmed in meta analysis. This can be caused by the cinnamon used in one study differing from the other in xenohormic properties.<ref name=":1">{{Cite journal|last1=Hooper|journal=Cell Stress & Chaperones|pmc=3024065|issn=1355-8145|doi=10.1007/s12192-010-0206-x|pages=761–770|issue=6|volume=15|title=Xenohormesis: health benefits from an eon of plant stress response evolution|first1=Philip L.|date=2010|first4=Lászlo|last4=Vígh|first3=Michael|last3=Tytell|first2=Paul L.|last2=Hooper|pmid=20524162}}</ref> | Xenohormesis could also explain several phenomena seen in the ethno-pharmaceutical (traditional medicine) side of things. Such as in the case of cinnamon, which in several studies have shown to help treat type 2 diabetes, but hasn't been confirmed in meta analysis. This can be caused by the cinnamon used in one study differing from the other in xenohormic properties.<ref name=":1">{{Cite journal|last1=Hooper|journal=Cell Stress & Chaperones|pmc=3024065|issn=1355-8145|doi=10.1007/s12192-010-0206-x|pages=761–770|issue=6|volume=15|title=Xenohormesis: health benefits from an eon of plant stress response evolution|first1=Philip L.|date=2010|first4=Lászlo|last4=Vígh|first3=Michael|last3=Tytell|first2=Paul L.|last2=Hooper|pmid=20524162}}</ref> | ||