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Cellular Senescence: Difference between revisions
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# '''T Cells''': Some types of T cells, especially CD4+ helper T cells and CD8+ cytotoxic T cells, can recognize and help eliminate senescent cells. | # '''T Cells''': Some types of T cells, especially CD4+ helper T cells and CD8+ cytotoxic T cells, can recognize and help eliminate senescent cells. | ||
# '''Senescence-Associated Secretory Phenotype (SASP)''': While the SASP is known for its pro-inflammatory properties, certain components of the SASP can attract immune cells to the location of the senescent cells, aiding in their clearance. | # '''Senescence-Associated Secretory Phenotype (SASP)''': While the SASP is known for its pro-inflammatory properties, certain components of the SASP can attract immune cells to the location of the senescent cells, aiding in their clearance. | ||
# '''Apoptosis''': In some circumstances, senescent cells can undergo programmed cell death, or apoptosis. While this isn't the immune system clearing them, it's a way for the body to rid itself of these cells. | # '''[[Apoptosis]]''': In some circumstances, senescent cells can undergo programmed cell death, or apoptosis. While this isn't the immune system clearing them, it's a way for the body to rid itself of these cells. | ||
In healthy young organisms, the immune system efficiently clears senescent cells, ensuring they don't accumulate in tissues. However, as organisms age and the immune system's function declines (a phenomenon known as immunosenescence), the removal of senescent cells becomes less efficient. This reduced clearance, combined with an increased rate of cells entering senescence, can result in the accumulation of senescent cells in tissues, contributing to aging and age-related diseases. | In healthy young organisms, the immune system efficiently clears senescent cells, ensuring they don't accumulate in tissues. However, as organisms age and the immune system's function declines (a phenomenon known as immunosenescence), the removal of senescent cells becomes less efficient. This reduced clearance, combined with an increased rate of cells entering senescence, can result in the accumulation of senescent cells in tissues, contributing to aging and age-related diseases. | ||