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Hallmarks of Aging: Difference between revisions
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| Altered Intercellular Communication | | Altered Intercellular Communication | ||
| Changes in cellular communication leading to inflammation and tissue dysfunction. | | Changes in cellular communication leading to inflammation and tissue dysfunction. | ||
|- | |||
! rowspan="5" |Proposed New Hallmarks | |||
|Compromised Autophagy | |||
|Impaired cellular maintenance through the consumption of own components. | |||
|- | |||
|Splicing Dysregulation | |||
|Impaired RNA construction from DNA, leading to cellular dysfunction. | |||
|- | |||
|Microbiome Disturbance | |||
|Changes in gut microbiome affecting health and aging. | |||
|- | |||
|Altered Mechanical Properties | |||
|Changes in cellular and extracellular structure affecting tissue function. | |||
|- | |||
|Inflammation (Inflammaging) | |||
|Systemic inflammation contributing to aging and related diseases. | |||
|} | |} | ||
==History== | |||
== | *'''2013''' The scientific journal ''Cell'' published the article "The Hallmarks of Aging", that was translated to several languages and determined the directions of many studies.{{pmid|23746838}} | ||
*'''2022''' It was proposed to expand the list of the nine hallmarks of aging with five more.{{pmid|36040386}}<ref>{{cite web|vauthors=Conway J|url=https://www.lifespan.io/news/researchers-propose-five-new-hallmarks-of-aging/|title=Researchers Propose Five New Hallmarks of Aging|work=[[Life Extension Advocacy Foundation|Lifespan.io]]|date=29 August 2022}}</ref> | |||
*'''2023''' In a paywalled review, the authors of a heavily cited paper on the hallmarks of aging update the set of proposed hallmarks after a decade.{{pmid|36599349}} A review with overlapping authors merge or link various hallmarks of cancer with those of aging.{{pmid|36599298}} | |||
==Todo== | |||
== References == | *{{pmid text|23746838}} | ||
*{{pmid text|37329949}} | |||
==References== | |||
<references /> | <references /> | ||
[[Category:Aging]] | [[Category:Aging]] | ||