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Hallmarks of Aging: Difference between revisions
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== Overview == | == Overview == | ||
[[File:Classification of Hallmarks of Aging.jpg|thumb|Scheme of the currently identified hallmarks of aging along with their classification.{{pmid|38095562}}]] | [[File:Classification of Hallmarks of Aging.jpg|thumb|Scheme of the currently identified hallmarks of aging along with their classification.{{pmid|38095562}}]] | ||
=== The Nine Hallmarks of Aging === | |||
{| class="wikitable" | |||
!# | |||
! Hallmark | |||
! | |||
|- | |||
|1 | |||
|'''Genomic Instability''' | |||
| rowspan="4" |'''Primary Hallmarks''' | |||
(causes damage) | |||
|- | |||
|2 | |||
|'''Telomere Attrition''' | |||
|- | |||
|3 | |||
|'''Epigenetic Alterations''' | |||
|- | |||
|4 | |||
|'''Loss of Proteostasis''' | |||
|- | |||
|5 | |||
|'''Deregulated Nutrient Sensing''' | |||
| rowspan="3" |'''Antagonistic Hallmarks''' | |||
(responses to damage) | |||
|- | |||
|6 | |||
|'''Mitochondrial Dysfunction''' | |||
|- | |||
|7 | |||
|[[Senescent Cells|'''Cellular Senescence''']] | |||
|- | |||
|8 | |||
|'''Stem Cell Exhaustion''' | |||
| rowspan="2" |'''Integrative Hallmarks''' | |||
(culprits of the phenotype) | |||
|- | |||
|9 | |||
|'''Altered Intercellular Communication''' | |||
|} | |||
=== The 14 Hallmarks of Aging (2023) === | |||
{| class="wikitable" | {| class="wikitable" | ||
!# | !# | ||