Hallmarks of Aging: Difference between revisions

Hallmarks of Aging (view source)

Revision as of 10:22, 3 January 2024

1,146 bytes removed , 3 January

→‎The Hallmarks in Detail

VisualWikitext

Strimo

Bureaucrats, Administrators

2,851

edits

@@ Line 172: / Line 172: @@
 | style="text-align:center; background-color:hsla(180, 100%, 85%);" |[[File:DNA Structure+Key+Labelled.pn NoBB.png|frameless|76x76px]]
 | style="background-color:hsla(180, 100%, 85%);" |'''Genomic instability'''
-| style="background-color:hsla(180, 100%, 85%);" |Damange in the DNA are formed mainly through oxidative stress and environmental factors.<ref>{{Cite journal|last=De Bont|first=R.|date=2004-05-01|title=Endogenous DNA damage in humans: a review of quantitative data|journal=Mutagenesis|language=en|volume=19|issue=3|pages=169–185|doi=10.1093/mutage/geh025|pmid=15123782|issn=1464-3804|doi-access=free}}</ref> A number of molecular processes work continuously to repair this damage.<ref>{{Cite journal|last=de Duve|first=Christian|date=2005-02-09|title=The onset of selection|journal=Nature|volume=433|issue=7026|pages=581–582|doi=10.1038/433581a|pmid=15703726|bibcode=2005Natur.433..581D|s2cid=4355530|issn=0028-0836|doi-access=free}}</ref>
+| style="background-color:hsla(180, 100%, 85%);" |Damange in the DNA are formed mainly through oxidative stress and environmental factors.{{pmid|15123782}} A number of molecular processes work continuously to repair this damage.{{pmid|15703726}}
-|DNA damage accumulates over time<ref name=":1">{{Cite journal|last1=Vijg|first1=Jan|last2=Suh|first2=Yousin|date=2013-02-10|title=Genome Instability and Aging|url=http://www.annualreviews.org/doi/10.1146/annurev-physiol-030212-183715|journal=Annual Review of Physiology|language=en|volume=75|issue=1|pages=645–668|doi=10.1146/annurev-physiol-030212-183715|pmid=23398157|issn=0066-4278}}</ref>
+|DNA damage accumulates over time{{pmid|23398157}}
-|Deficient DNA repair causes premature aging<ref name=":0">{{Cite journal|last=Hoeijmakers|first=Jan H.J.|date=2009-10-08|title=DNA Damage, Aging, and Cancer|url=http://www.nejm.org/doi/abs/10.1056/NEJMra0804615|journal=New England Journal of Medicine|language=en|volume=361|issue=15|pages=1475–1485|doi=10.1056/NEJMra0804615|pmid=19812404|issn=0028-4793}}</ref>
+|Deficient DNA repair causes premature aging{{pmid|19812404}}
-|Increased DNA repair facilitates greater longevity<ref name=":0" />
+|Increased DNA repair facilitates greater longevity{{pmid|19812404}}
 |-
 | style="text-align:center; background-color:hsla(180, 100%, 85%);" |[[File:Telomeres transparent.png|frameless|88x88px]]