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Stem Cell Exhaustion: Difference between revisions
→Factors Contributing to Stem Cell Exhaustion
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==Factors Contributing to Stem Cell Exhaustion== | ==Factors Contributing to Stem Cell Exhaustion== | ||
Several factors contribute to the decline in stem cell function with age: | Several factors contribute to the decline in stem cell function with age: | ||
*'''Genomic Instability''': Accumulation of DNA damage over time impairs the function and survival of stem cells, leading to decreased regenerative capacity. | *'''[[Genomic Instability]]''': Accumulation of DNA damage over time impairs the function and survival of stem cells, leading to decreased regenerative capacity. | ||
*'''Telomere Attrition''': The gradual shortening of telomeres during cell division leads to cellular aging and senescence, reducing the proliferative capacity of stem cells. | *'''[[Telomere Attrition]]''': The gradual shortening of telomeres during cell division leads to cellular aging and senescence, reducing the proliferative capacity of stem cells. | ||
*'''Epigenetic Alterations''': Changes in the epigenetic landscape can lead to altered gene expression patterns, affecting stem cell identity and function. | *'''[[Epigenetic Alterations]]''': Changes in the epigenetic landscape can lead to altered gene expression patterns, affecting stem cell identity and function. | ||
*'''Cellular Senescence''': The increase in senescent cells within the stem cell niche and throughout the body can disrupt the local tissue environment and inhibit stem cell function. | *'''[[Cellular Senescence]]''': The increase in senescent cells within the stem cell niche and throughout the body can disrupt the local tissue environment and inhibit stem cell function. | ||
*'''Systemic Changes''': Age-related changes in the systemic environment, including altered levels of hormones and growth factors, can affect stem cell behavior and reduce their regenerative potential. | *'''Systemic Changes''': Age-related changes in the systemic environment, including altered levels of hormones and growth factors, can affect stem cell behavior and reduce their regenerative potential. | ||
==Impact of Stem Cell Exhaustion== | ==Impact of Stem Cell Exhaustion== | ||