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Genomic Instability: Difference between revisions
→Cellular Response to Genomic Instability
(Created page with "'''Genomic instability''' refers to the increased tendency of alterations in the genome during the life cycle of cells. It is a hallmark of aging and is characterized by a hig...") |
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*'''DNA Repair Pathways''': Cells have several DNA repair pathways to fix different types of DNA damage. These include base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair mechanisms. | *'''DNA Repair Pathways''': Cells have several DNA repair pathways to fix different types of DNA damage. These include base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair mechanisms. | ||
*'''Cell Cycle Arrest''': In response to DNA damage, cells can halt their cell cycle to provide time for repair. This is mediated by checkpoint proteins like p53. | *'''Cell Cycle Arrest''': In response to DNA damage, cells can halt their cell cycle to provide time for repair. This is mediated by checkpoint proteins like p53. | ||
*'''Apoptosis''': If damage is too severe, cells can undergo programmed cell death to prevent the propagation of the instability. | *'''[[Apoptosis]]''': If damage is too severe, cells can undergo programmed cell death to prevent the propagation of the instability. | ||
*'''Senescence''': Cells may also enter a state of permanent cell cycle arrest known as senescence, where they remain metabolically active but no longer divide. | *'''[[Cellular Senescence]]''': Cells may also enter a state of permanent cell cycle arrest known as senescence, where they remain metabolically active but no longer divide. | ||
==Research and Therapeutic Implications== | ==Research and Therapeutic Implications== | ||
Research into genomic instability has significant implications for aging and disease treatment: | Research into genomic instability has significant implications for aging and disease treatment: | ||