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Brain Aging: Difference between revisions
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Significant dynamic changes in brain structure take place through adulthood and aging, with substantial variation between individuals. In later decades, men show greater volume loss in whole brain volume and in the [[frontal lobes]], and [[temporal lobes]], whereas in women there is increased volume loss in the [[Hippocampus|hippocampi]] and [[parietal lobes]].<ref name="Kelly2007" /> Men show a steeper decline in global gray matter volume, although in both sexes it varies by region with some areas exhibiting little or no age effect. Overall white matter volume does not appear to decline with age, although there is variation between brain regions.<ref>{{cite journal |last1=Good |first1=Catriona D. |last2=Johnsrude |first2=Ingrid S. |last3=Ashburner |first3=John |last4=Henson |first4=Richard N.A. |last5=Friston |first5=Karl J. |last6=Frackowiak |first6=Richard S.J. |title=A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains |journal=NeuroImage |date=July 2001 |volume=14 |issue=1 |pages=21–36 |doi=10.1006/nimg.2001.0786 |pmid=11525331 |s2cid=6392260 |url=http://pdfs.semanticscholar.org/1043/8bd0e1231dc8bf12ec3f407b5a6a7aa026c9.pdf |archive-url=https://web.archive.org/web/20201117094046/http://pdfs.semanticscholar.org/1043/8bd0e1231dc8bf12ec3f407b5a6a7aa026c9.pdf |url-status=dead |archive-date=2020-11-17 }}</ref> | Significant dynamic changes in brain structure take place through adulthood and aging, with substantial variation between individuals. In later decades, men show greater volume loss in whole brain volume and in the [[frontal lobes]], and [[temporal lobes]], whereas in women there is increased volume loss in the [[Hippocampus|hippocampi]] and [[parietal lobes]].<ref name="Kelly2007" /> Men show a steeper decline in global gray matter volume, although in both sexes it varies by region with some areas exhibiting little or no age effect. Overall white matter volume does not appear to decline with age, although there is variation between brain regions.<ref>{{cite journal |last1=Good |first1=Catriona D. |last2=Johnsrude |first2=Ingrid S. |last3=Ashburner |first3=John |last4=Henson |first4=Richard N.A. |last5=Friston |first5=Karl J. |last6=Frackowiak |first6=Richard S.J. |title=A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains |journal=NeuroImage |date=July 2001 |volume=14 |issue=1 |pages=21–36 |doi=10.1006/nimg.2001.0786 |pmid=11525331 |s2cid=6392260 |url=http://pdfs.semanticscholar.org/1043/8bd0e1231dc8bf12ec3f407b5a6a7aa026c9.pdf |archive-url=https://web.archive.org/web/20201117094046/http://pdfs.semanticscholar.org/1043/8bd0e1231dc8bf12ec3f407b5a6a7aa026c9.pdf |url-status=dead |archive-date=2020-11-17 }}</ref> | ||
== Research Statistics == | |||
== Further Reading == | == Further Reading == | ||