Deregulated Nutrient Sensing: Difference between revisions

Deregulated Nutrient Sensing (view source)

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 ==Key Nutrient Sensing Pathways==
 Several critical nutrient-sensing pathways are known to be involved in the regulation of metabolism and aging:
-*'''Insulin and Insulin-Like Growth Factor 1 (IGF-1) Signaling (IIS)''': IIS is crucial for controlling growth and metabolism in response to nutrient availability. Dysregulation of IIS is associated with various metabolic disorders, including diabetes and obesity, and modulating this pathway has been shown to affect lifespan in various organisms.
+*'''Insulin and IGF-1 Signaling (IIS)''': IIS is crucial for controlling growth and metabolism in response to nutrient availability. Dysregulation of IIS is associated with various metabolic disorders, including diabetes and obesity, and modulating this pathway has been shown to affect lifespan in various organisms.
 *'''mTOR Pathway''': The mechanistic target of rapamycin (mTOR) pathway integrates signals from nutrients, growth factors, and energy status to regulate growth, protein synthesis, and autophagy. Overactivation of mTOR is linked to accelerated aging and age-related diseases, while its inhibition has been associated with lifespan extension.
 *'''AMP-Activated Protein Kinase (AMPK)''': AMPK is activated under low energy conditions and helps restore energy balance by promoting catabolic processes and inhibiting anabolic processes. It plays a critical role in maintaining energy homeostasis and is considered a key target for treating metabolic diseases.