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Sirtuins: Difference between revisions
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* '''Caloric Restriction Mimicry:''' Sirtuins are known to mimic some of the effects of caloric restriction, a dietary regimen known to extend lifespan in several species. This has led to the hypothesis that sirtuin activation could be a key mechanism behind the benefits of caloric restriction on longevity. | * '''Caloric Restriction Mimicry:''' Sirtuins are known to mimic some of the effects of caloric restriction, a dietary regimen known to extend lifespan in several species. This has led to the hypothesis that sirtuin activation could be a key mechanism behind the benefits of caloric restriction on longevity. | ||
* '''Cellular Resilience:''' Sirtuins enhance cellular resilience by promoting DNA repair, reducing oxidative stress, and regulating cellular metabolism. These factors collectively contribute to an organism's ability to withstand the challenges of aging. | * '''Cellular Resilience:''' Sirtuins enhance cellular resilience by promoting DNA repair, reducing [[Oxidative Stress|oxidative stress]], and regulating cellular metabolism. These factors collectively contribute to an organism's ability to withstand the challenges of aging. | ||
=== Research on Sirtuins and Aging === | === Research on Sirtuins and Aging === | ||
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* '''Neurogenesis:''' Sirtuins support the growth of new neurons (neurogenesis) and enhance synaptic plasticity, which is essential for learning and memory. | * '''Neurogenesis:''' Sirtuins support the growth of new neurons (neurogenesis) and enhance synaptic plasticity, which is essential for learning and memory. | ||
* '''Neurodegenerative Diseases:''' Research suggests that sirtuins may help protect against neurodegenerative diseases like Alzheimer's and Parkinson's by reducing oxidative stress and inflammation in the brain. | * '''Neurodegenerative Diseases:''' Research suggests that sirtuins may help protect against neurodegenerative diseases like Alzheimer's and Parkinson's by reducing [[Oxidative Stress|oxidative stress]] and inflammation in the brain. | ||
=== Cardiovascular Health === | === Cardiovascular Health === | ||