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Resveratrol/en: Difference between revisions
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One of the mechanisms by which resveratrol is thought to impact aging is by mimicking the effects of [[Caloric Restriction|caloric restriction]], a well-known intervention for extending lifespan. It activates [[Sirtuins|sirtuins]] (in particularly [[SIRT1]]), proteins associated with longevity, and influences metabolic processes related to aging. | One of the mechanisms by which resveratrol is thought to impact aging is by mimicking the effects of [[Caloric Restriction|caloric restriction]], a well-known intervention for extending lifespan. It activates [[Sirtuins|sirtuins]] (in particularly [[SIRT1]]), proteins associated with longevity, and influences metabolic processes related to aging. | ||
A | A 2023 [[Randomized Controlled Trial|randomized control trial]]{{pmid|37447275}} involving 48 adults aged 55 to 65 compared the effects of resveratrol supplementation to a caloric-restricted diet. Both interventions raised circulating SIRT1 levels and reduced plasma noradrenaline, suggesting cardiovascular benefits. However, the study found differences between the groups in vascular reactions. Specifically, improvements in [[Nitrate-Mediated Vasodilation (NMD)|nitrate-mediated vasodilation (NMD)]] were seen only with caloric restriction, not with resveratrol. Additionally, SIRT1 was linked to enhanced flow-mediated vasodilation (FMD) in men but not in women. This suggests that while resveratrol mirrors some benefits of caloric restriction, it doesn't capture all, especially regarding vascular effects. | ||
==Forms of Resveratrol == | ==Forms of Resveratrol == | ||