2,851
edits
Cellular Senescence: Difference between revisions
no edit summary
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
Cellular senescence, a state in which cells lose their ability to divide and function properly, is a | Cellular senescence, a state in which cells lose their ability to divide and function properly, is a pivotal concept in the study of aging and longevity. This phenomenon is intricately linked with the Hayflick limit, named after biologist Leonard Hayflick, who discovered in the 1960s that most somatic cells have a limited capacity to divide, typically around 40 to 60 times, before they enter senescence. The limitation arises primarily due to telomere shortening—the protective ends of chromosomes that diminish with each cellular division. Once telomeres reach a critical length, the cell perceives it as DNA damage, prompting cell cycle arrest and thereby preventing potential genetic instability. Cellular senescence serves as a double-edged sword. On one hand, it acts as a protective mechanism against cancer, ensuring that damaged cells don't proliferate uncontrollably. On the other, the accumulation of senescent cells contributes to aging and various age-related diseases. As the field of longevity research advances, understanding and addressing the nuances of cellular senescence will be key. Strategies that target senescence, either by removing these cells or modulating their effects, offer promising avenues for enhancing healthspan and potentially extending lifespan. | ||
== Definition and Characteristics == | == Definition and Characteristics == | ||