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Trimethylglycine (TMG): Difference between revisions
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Although trimethylglycine supplementation decreases the amount of [[wikipedia:Adipose_tissue|adipose tissue]] in pigs, research on human subjects has shown no effect on body weight, body composition, or resting energy expenditure when used in conjunction with a low calorie diet.<ref name="pmid12399266">{{cite journal|last1=Schwab|volume=76|doi-access=free|doi=10.1093/ajcn/76.5.961|pmid=12399266|date=November 2002|pages=961–967|issue=5|journal=Am. J. Clin. Nutr.|first1=U.|title=Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects|display-authors=etal|first3=L.|last3=Toppinen|first2=A.|last2=Törrönen|title-link=doi}}</ref> | Although trimethylglycine supplementation decreases the amount of [[wikipedia:Adipose_tissue|adipose tissue]] in pigs, research on human subjects has shown no effect on body weight, body composition, or resting energy expenditure when used in conjunction with a low calorie diet.<ref name="pmid12399266">{{cite journal|last1=Schwab|volume=76|doi-access=free|doi=10.1093/ajcn/76.5.961|pmid=12399266|date=November 2002|pages=961–967|issue=5|journal=Am. J. Clin. Nutr.|first1=U.|title=Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects|display-authors=etal|first3=L.|last3=Toppinen|first2=A.|last2=Törrönen|title-link=doi}}</ref> | ||
==== Side effects | == Taking TMG == | ||
=== Side effects === | |||
Trimethylglycine supplementation may cause [[wikipedia:Diarrhea|diarrhea]], bloating, cramps, dyspepsia, [[wikipedia:Nausea|nausea]] or vomiting.<ref name=":0">{{Citation|title=Betaine|date=2012|url=http://www.ncbi.nlm.nih.gov/books/NBK548774/|work=LiverTox: Clinical and Research Information on Drug-Induced Liver Injury|access-date=2023-07-14|place=Bethesda (MD)|publisher=National Institute of Diabetes and Digestive and Kidney Diseases|pmid=31644082}}</ref> Although rare, it can also causes excessive increases in serum methionine concentrations in the brain, which may lead to [[wikipedia:Cerebral_edema|cerebral edema]], a life-threatening condition.<ref name=":0" /> | Trimethylglycine supplementation may cause [[wikipedia:Diarrhea|diarrhea]], bloating, cramps, dyspepsia, [[wikipedia:Nausea|nausea]] or vomiting.<ref name=":0">{{Citation|title=Betaine|date=2012|url=http://www.ncbi.nlm.nih.gov/books/NBK548774/|work=LiverTox: Clinical and Research Information on Drug-Induced Liver Injury|access-date=2023-07-14|place=Bethesda (MD)|publisher=National Institute of Diabetes and Digestive and Kidney Diseases|pmid=31644082}}</ref> Although rare, it can also causes excessive increases in serum methionine concentrations in the brain, which may lead to [[wikipedia:Cerebral_edema|cerebral edema]], a life-threatening condition.<ref name=":0" /> | ||
Trimethylglycine supplementation lowers homocysteine but also raises [[wikipedia:LDL-cholesterol|LDL-cholesterol]] in obese individuals and renal patients.<ref>{{cite journal|vauthors=Olthof MR, van Vliet T, Verhoef P, Zock PL, Katan MB|title=Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans|journal=PLOS Med.|volume=2|issue=5|pages=e135|year=2005|pmid=15916468|pmc=1140947|doi=10.1371/journal.pmed.0020135}}</ref> | Trimethylglycine supplementation lowers homocysteine but also raises [[wikipedia:LDL-cholesterol|LDL-cholesterol]] in obese individuals and renal patients.<ref>{{cite journal|vauthors=Olthof MR, van Vliet T, Verhoef P, Zock PL, Katan MB|title=Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans|journal=PLOS Med.|volume=2|issue=5|pages=e135|year=2005|pmid=15916468|pmc=1140947|doi=10.1371/journal.pmed.0020135}}</ref> | ||
== References == | |||
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