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S-Adenosylmethionine (SAMe): Difference between revisions
S-Adenosylmethionine (SAMe) (view source)
Revision as of 03:21, 21 September 2023
, 21 September 2023→Supplementation and Safety
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SAMe has been available as a dietary supplement in the US since the 1990s. It's often taken for mood support, liver health, and joint health. While many studies indicate SAMe has a good safety profile, some side effects have been noted, including digestive issues, dry mouth, and, in rare cases, increased anxiety. | SAMe has been available as a dietary supplement in the US since the 1990s. It's often taken for mood support, liver health, and joint health. While many studies indicate SAMe has a good safety profile, some side effects have been noted, including digestive issues, dry mouth, and, in rare cases, increased anxiety. | ||
Long-term | However, when considering SAMe in the context of longevity: | ||
* '''Limited Long-Term Data''': The long-term consequences of SAMe supplementation on human longevity remain elusive. While initial research underscores benefits for mood, joint health, and liver vitality, its direct influence on lifespan or healthspan requires further investigation. | |||
* '''Uncertain Optimal Dosages''': Dosage recommendations for SAMe vary based on the intended health benefit. Doses between 400 to 1600 mg daily have been suggested for mood enhancement and cognitive health. However, for longevity, a precise, universally recommended dosage remains undefined. Moreover, individual factors such as metabolic differences, pre-existing health conditions, and genetic factors can affect the optimal dose. | |||
* '''Risks of Over-Supplementation''': Exceeding the ideal SAMe intake may disturb the intricate balance of methylation processes. Proper methylation is integral to numerous cellular functions, including DNA maintenance and gene regulation. Overloading the system with SAMe could potentially disrupt these processes, possibly expediting aging or amplifying risks for specific age-related conditions. Additionally, overconsumption may manifest side effects like gastrointestinal discomfort. | |||
[[Category:Orally Consumable Longevity Molecules]] | [[Category:Orally Consumable Longevity Molecules]] | ||