NADase: Difference between revisions

NADase (view source)

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→‎Known NADase Enzymes

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 == Known NADase Enzymes ==
-NADase or NAD^+ase enzymes have implications in longevity due to their impact on [[NAD+]] levels within cells. NAD+ is crucial for cellular energy metabolism and maintenance of proper cellular function. Here is some information on known NADase enzymes:
+NADase or NAD^+ase enzymes have implications in longevity due to their impact on [[NAD+]] levels within cells. NAD+ is crucial for cellular energy metabolism and maintenance of proper cellular function. Here is some information on known NADase enzymes.
-=== CD38 ===
+{| class="wikitable" style="width:100%; text-align:left;"
-'''CD38''' is a multifunctional enzyme expressed in various tissues, playing a crucial role in calcium signaling, cell adhesion, and immune response. It is one of the primary NADase enzymes in mammals, including humans, and is responsible for the hydrolysis of NAD+.
+|-
+! Enzyme!! Description!!Function!!Location/Expression!!Implications in Aging!!Associated Diseases
+|-
+|'''[[CD38]]'''||CD38 is a multifunctional enzyme involved in calcium signaling and plays a role in immune response, cellular metabolism, and NAD+ homeostasis.||Calcium signaling, cell adhesion, immune response.||Widely expressed in various tissues, including immune cells.||Involved in cellular aging processes, and its activity has been linked to a reduction in cellular NAD+ levels.||Chronic inflammatory conditions, some leukemias
+|-
+|'''[[CD157]]'''||CD157, also known as bone marrow stromal antigen 1, is involved in monocyte and neutrophil infiltration during inflammatory responses and has implications in leukocyte trafficking.||Monocyte and neutrophil infiltration during inflammatory responses.||Primarily expressed in bone marrow and myeloid cells.||Its roles in inflammation might have implications in aging-related inflammatory conditions.||Autoimmune diseases, some cancers
+|-
+|'''[[SARM1]]'''||SARM1 (Sterile Alpha and TIR Motif Containing 1) is predominantly known for its role in programmed axon degeneration and has implications in neurodegenerative conditions.||Induces axonal degeneration after injury, involved in innate immune response.||Predominantly expressed in the nervous system.||Its role in axon degeneration has implications in aging-related neurodegenerative conditions.||Neurodegenerative diseases
+|}
-:''Main article: [[CD38]]''
+== See also ==
-=== CD157 ===
+* [[Wikipedia:NAD+ glycohydrolase|Wikipedia article]]
-'''CD157''', also known as bone marrow stromal antigen 1 (BST-1), is a glycosylphosphatidylinositol-anchored NADase. It shares structural similarities with CD38 and is involved in monocyte and neutrophil infiltration during inflammatory responses.
-:''Main article: [[CD157]]''
-=== SARM1 ===
-'''SARM1''' (Sterile Alpha and TIR Motif Containing 1) is a recently characterized NADase. It plays a critical role in Wallerian degeneration, a process where damaged neurons degenerate. SARM1 is activated under conditions of cellular stress and can lead to rapid depletion of intracellular NAD+ levels.
-:''Main article: [[SARM1]]''
-These enzymes, by modulating NAD+ levels, indirectly influence the aging process, cellular repair mechanisms, and overall cellular health. Modulating the activity of these enzymes has become a focal point in longevity and aging research, targeting the restoration of cellular NAD+ levels to maintain cellular function and mitigate age-related decline.