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Quercetin: Difference between revisions
→Clinical Applications and Effects on Longevity
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'''Quercetin''' has been the focus of numerous clinical studies aiming to understand its potential applications and efficacy in addressing age-related conditions and promoting longevity due to its diverse biological activities. | '''Quercetin''' has been the focus of numerous clinical studies aiming to understand its potential applications and efficacy in addressing age-related conditions and promoting longevity due to its diverse biological activities. | ||
; Anti-inflammatory Effects | |||
Quercetin’s potent anti-inflammatory properties have led to its investigation for use in chronic inflammatory conditions such as arthritis and cardiovascular diseases. It modulates inflammatory pathways by inhibiting the release of pro-inflammatory cytokines and reducing the activation of inflammatory cells. | : Quercetin’s potent anti-inflammatory properties have led to its investigation for use in chronic inflammatory conditions such as arthritis and cardiovascular diseases. It modulates inflammatory pathways by inhibiting the release of pro-inflammatory cytokines and reducing the activation of inflammatory cells. | ||
; Antioxidant Properties | |||
The antioxidant activity of quercetin is attributed to its ability to neutralize free radicals and reduce oxidative stress, potentially mitigating aging-related cellular damage and dysfunction. Its antioxidant properties are linked to a reduction in the risk of chronic conditions such as cancer and neurodegenerative diseases. | : The antioxidant activity of quercetin is attributed to its ability to neutralize free radicals and reduce oxidative stress, potentially mitigating aging-related cellular damage and dysfunction. Its antioxidant properties are linked to a reduction in the risk of chronic conditions such as cancer and neurodegenerative diseases. | ||
; Impact on Cellular Senescence | |||
Research has indicated that quercetin may delay cellular senescence by modulating senescence-associated signaling pathways and reducing the accumulation of senescent cells, potentially impacting aging processes and age-related diseases. | : Research has indicated that quercetin may delay cellular senescence by modulating senescence-associated signaling pathways and reducing the accumulation of senescent cells, potentially impacting aging processes and age-related diseases. | ||
; Clinical Studies and Trials related to Aging | |||
Several clinical trials and studies have been conducted to assess the safety and efficacy of quercetin supplementation in age-related conditions. The data, however, are still inconclusive, necessitating further well-designed studies to establish its therapeutic benefits in aging and longevity comprehensively. | : Several clinical trials and studies have been conducted to assess the safety and efficacy of quercetin supplementation in age-related conditions. The data, however, are still inconclusive, necessitating further well-designed studies to establish its therapeutic benefits in aging and longevity comprehensively. | ||
; Role as an NAD+ Booster | |||
Quercetin has been identified as a potential NAD+ booster | : Quercetin has been identified as a potential NAD+ booster. Studies have demonstrated that quercetin can inhibit the activity of [[NADase]] ([[CD38]]), an enzyme responsible for the degradation of NAD+, thus potentially increasing the levels of NAD+ in cells. Elevated NAD+ levels are associated with improved mitochondrial function, enhanced cellular metabolism, and reduced oxidative stress, all of which are key components in the aging process. | ||
Studies have demonstrated that quercetin can inhibit the activity of [[NADase]] ([[CD38]]), an enzyme responsible for the degradation of NAD+, thus potentially increasing the levels of NAD+ in cells. Elevated NAD+ levels are associated with improved mitochondrial function, enhanced cellular metabolism, and reduced oxidative stress, all of which are key components in the aging process. | |||
==Dosage and Administration== | ==Dosage and Administration== | ||