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Quercetin: Difference between revisions
→Quercetin LipoMicel
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In a study sponsored by Natural Factors, the bioavailability of Standard Quercetin, Quercetin Phytosome and Quercetin LipoMicel was evaluated. The results indicated that Quercetin LipoMicel had a relative bioavailability to Standard Quercetin of 8.5, while Quercetin Phytosome exhibited a slightly higher value of 8.9. Notably, LipoMicel maintained more consistent levels of quercetin in the system over a 24-hour period. <ref name=":1">https://jnhpresearch.com/index.php/jnhpr/article/view/17/24</ref> | In a study sponsored by Natural Factors, the bioavailability of Standard Quercetin, Quercetin Phytosome and Quercetin LipoMicel was evaluated. The results indicated that Quercetin LipoMicel had a relative bioavailability to Standard Quercetin of 8.5, while Quercetin Phytosome exhibited a slightly higher value of 8.9. Notably, LipoMicel maintained more consistent levels of quercetin in the system over a 24-hour period. <ref name=":1">https://jnhpresearch.com/index.php/jnhpr/article/view/17/24</ref> | ||
In a second study, the blood concentrations of quercetin in healthy participants after the administration of standard quercetin and LipeMice quercetin was evaluated with over 72 hours and 4 doses in total. Within the first 24 hours, LipeMice (500mg) had a significantly 7-fold increased blood concentrations of quercetin compared to standard quercetin (500 mg). LipeMice administered at a double dose (1000 mg) achieved 15-fold higher absorption, LipeMice tested at half a dose of standard quercetin increased concentration by approx. 3-fold. Quercetin blood concentrations were attained over 72 hours. <ref name=":2">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435304/</ref> | |||
{| class="wikitable" | {| class="wikitable" | ||
|+[[Pharmacokinetic]] parameters | |+[[Pharmacokinetic]] parameters | ||
! | ! | ||
!Quercetin 500mg | ! colspan="3" |Study 1 <ref name=":1" /> | ||
!Quercetin LipoMicel 500mg | ! colspan="4" |Study 2 <ref name=":2" /> | ||
!Quercetin Phytosome 500mg | |- | ||
! | |||
!Quercetin | |||
500mg | |||
!Quercetin LipoMicel | |||
500mg | |||
!Quercetin Phytosome | |||
500mg | |||
!Quercetin | |||
500mg | |||
!Quercetin LipoMicel | |||
250mg | |||
!Quercetin LipoMicel | |||
500mg | |||
!Quercetin LipoMicel | |||
1000mg | |||
|- | |- | ||
|[[AUClast|AUC<sub>0-24</sub>]] (ng h/ml) | |[[AUClast|AUC<sub>0-24</sub>]] (ng h/ml) | ||
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| 1477.27 ± 25.57 | | 1477.27 ± 25.57 | ||
| 1536.00 ± 115.66 | | 1536.00 ± 115.66 | ||
|77.3 (SD=6.1) | |||
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|- | |- | ||
| colspan="1" rowspan="1" |[[Cmax|C<sub>max</sub>]] (ng/ml) | | colspan="1" rowspan="1" |[[Cmax|C<sub>max</sub>]] (ng/ml) | ||
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| 182.85 ± 106.64 | | 182.85 ± 106.64 | ||
| 150.27 ± 61.43 | | 150.27 ± 61.43 | ||
|197.0 (SD=8.0 | |||
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|- | |- | ||
| colspan="1" rowspan="1" |[[Time to Maximum Concentration (Tmax)|T<sub>max</sub>]] (hours) | | colspan="1" rowspan="1" |[[Time to Maximum Concentration (Tmax)|T<sub>max</sub>]] (hours) | ||
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| 0.5 ± 0.02 | | 0.5 ± 0.02 | ||
| 1 ± 0.30 | | 1 ± 0.30 | ||
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| colspan="1" rowspan="1" |[[Elimination Half-Life|''t''<sub>1/2</sub>]] (hours) | | colspan="1" rowspan="1" |[[Elimination Half-Life|''t''<sub>1/2</sub>]] (hours) | ||
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| 8.29 ± 0.49 | | 8.29 ± 0.49 | ||
| 6.02 ± 0.52 | | 6.02 ± 0.52 | ||
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|} | |} | ||