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SIRT1: Difference between revisions
→SIRT1 Activating Compounds (STACs)
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==== SIRT1 Activating Compounds (STACs) ==== | ==== SIRT1 Activating Compounds (STACs) ==== | ||
Resveratrol is one of the most well-known and studied SIRT1 Activating Compounds (STACs). It is a natural polyphenolic compound found in grapes, berries, peanuts, and red wine. | [[Resveratrol]] is one of the most well-known and studied SIRT1 Activating Compounds (STACs). It is a natural polyphenolic compound found in grapes, berries, peanuts, and red wine. Resveratrol mimics the effects of caloric restriction by modulating the same pathways and has shown to confer protective effects against various diseases, including cardiovascular and neurodegenerative diseases. | ||
In addition to resveratrol, several other synthetic and natural STACs have been identified, such as SRT1720, SRT2104, and [[Quercetin|quercetin]]. These compounds have demonstrated the potential to enhance SIRT1 activity, modulate metabolic processes, and extend lifespan in various animal models. The translational potential of these compounds, including resveratrol, to human health and longevity remains to be fully elucidated, with ongoing studies aimed at understanding their efficacy, optimal dosages, and mechanisms of action. | In addition to resveratrol, several other synthetic and natural STACs have been identified, such as SRT1720, SRT2104, and [[Quercetin|quercetin]]. These compounds have demonstrated the potential to enhance SIRT1 activity, modulate metabolic processes, and extend lifespan in various animal models. The translational potential of these compounds, including resveratrol, to human health and longevity remains to be fully elucidated, with ongoing studies aimed at understanding their efficacy, optimal dosages, and mechanisms of action. | ||