Cold Therapy

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David Sinclair mentioned in ^[1] that he has a bed that you can control the temperature and he sets it a bit cooler duing the night

Todo

2011, Using Drosophila melanogaster to study the positive effects of mild stress on aging ^[2]
2012, [Mild stress as a means to modulate aging: from fly to human?] ^[3]
2013, Life extension after heat shock exposure: assessing meta-analytic evidence for hormesis ^[4]

References

↑ 2022-09-02 - Interview Dr. David Sinclair - Optimize Longevity - Keeping Your Brain Young
↑ Le Bourg E: Using Drosophila melanogaster to study the positive effects of mild stress on aging. Exp Gerontol 2011. (PMID 20727961) [PubMed] [DOI] Abstract
Several studies in the fly Drosophila melanogaster have shown that a mild stress can increase longevity, resistance to strong stresses (e.g., heat, fungal infection, cold) and delay behavioral aging. However, not all mild stresses have similar effects on the various studied traits. For instance, exposure to cold increases resistance to a fungal infection, but hypergravity and heat shocks do not. In addition to studies in flies and other invertebrates, it is necessary to perform experiments in mammals, to know whether mild stress could be used in therapy more thoroughly than today.
↑ Le Bourg É: [Mild stress as a means to modulate aging: from fly to human?]. Med Sci (Paris) 2012. (PMID 22480655) [PubMed] [DOI] Abstract
Hormesis is the phenomenon by which adaptive responses to low doses of otherwise harmful conditions improve the functional ability of organisms. Some mild stresses have beneficial effects on longevity, aging and resistance to strong stresses (heat or cold shocks, infection) in Drosophila flies. Studies on rodents are indeed scarce but mild stress seems to be effective in humans because, for instance, patients suffering from angina have a higher survival when confronted with a heart attack. A few studies, in less tragic situations however, suggest that mild stress could have positive effects in elderly people. Performing more experiments on the effects of mild stress in humans would help to know whether it could be used in therapy or to improve healthspan of elderly.
↑ Lagisz M et al.: Life extension after heat shock exposure: assessing meta-analytic evidence for hormesis. Ageing Res Rev 2013. (PMID 23570942) [PubMed] [DOI] Abstract
Hormesis is the response of organisms to a mild stressor resulting in improved health and longevity. Mild heat shocks have been thought to induce hormetic response because they promote increased activity of heat shock proteins (HSPs), which may extend lifespan. Using data from 27 studies on 12 animal species, we performed a comparative meta-analysis to quantify the effect of heat shock exposure on longevity. Contrary to our expectations, heat shock did not measurably increase longevity in the overall meta-analysis, although we observed much heterogeneity among studies. Thus, we explored the relative contributions of different experimental variables (i.e. moderators). Higher temperatures, longer durations of heat shock exposure, increased shock repeat and less time between repeat shocks, all decreased the likelihood of a life-extending effect, as would be expected when a hormetic response crosses the threshold to being a damaging exposure. We conclude that there is limited evidence that mild heat stress is a universal way of promoting longevity at the whole-organism level. Life extension via heat-induced hormesis is likely to be constrained to a narrow parameter window of experimental conditions.

[1] 2022-09-02 - Interview Dr. David Sinclair - Optimize Longevity - Keeping Your Brain Young

[pmid20727961-2] Le Bourg E: Using Drosophila melanogaster to study the positive effects of mild stress on aging. Exp Gerontol 2011. (PMID 20727961) [PubMed] [DOI] Abstract
Several studies in the fly Drosophila melanogaster have shown that a mild stress can increase longevity, resistance to strong stresses (e.g., heat, fungal infection, cold) and delay behavioral aging. However, not all mild stresses have similar effects on the various studied traits. For instance, exposure to cold increases resistance to a fungal infection, but hypergravity and heat shocks do not. In addition to studies in flies and other invertebrates, it is necessary to perform experiments in mammals, to know whether mild stress could be used in therapy more thoroughly than today.

[pmid22480655-3] Le Bourg É: [Mild stress as a means to modulate aging: from fly to human?]. Med Sci (Paris) 2012. (PMID 22480655) [PubMed] [DOI] Abstract
Hormesis is the phenomenon by which adaptive responses to low doses of otherwise harmful conditions improve the functional ability of organisms. Some mild stresses have beneficial effects on longevity, aging and resistance to strong stresses (heat or cold shocks, infection) in Drosophila flies. Studies on rodents are indeed scarce but mild stress seems to be effective in humans because, for instance, patients suffering from angina have a higher survival when confronted with a heart attack. A few studies, in less tragic situations however, suggest that mild stress could have positive effects in elderly people. Performing more experiments on the effects of mild stress in humans would help to know whether it could be used in therapy or to improve healthspan of elderly.

[pmid23570942-4] Lagisz M et al.: Life extension after heat shock exposure: assessing meta-analytic evidence for hormesis. Ageing Res Rev 2013. (PMID 23570942) [PubMed] [DOI] Abstract
Hormesis is the response of organisms to a mild stressor resulting in improved health and longevity. Mild heat shocks have been thought to induce hormetic response because they promote increased activity of heat shock proteins (HSPs), which may extend lifespan. Using data from 27 studies on 12 animal species, we performed a comparative meta-analysis to quantify the effect of heat shock exposure on longevity. Contrary to our expectations, heat shock did not measurably increase longevity in the overall meta-analysis, although we observed much heterogeneity among studies. Thus, we explored the relative contributions of different experimental variables (i.e. moderators). Higher temperatures, longer durations of heat shock exposure, increased shock repeat and less time between repeat shocks, all decreased the likelihood of a life-extending effect, as would be expected when a hormetic response crosses the threshold to being a damaging exposure. We conclude that there is limited evidence that mild heat stress is a universal way of promoting longevity at the whole-organism level. Life extension via heat-induced hormesis is likely to be constrained to a narrow parameter window of experimental conditions.

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