Lifespan: Why We Age – and Why We Don't Have To

Lifespan: Why We Age – and Why We Don't Have To is a book by David A. Sinclair.

Synopsis

Lifespan has three parts:

• "Part I: What We Know (The Past)" – contains 3 chapters
• "Part II: What We're Learning (The Present)" – contains 4 chapters
• "Part III: Where We're Going (The Future)" – contains 2 chapters

The book also contains an introduction and conclusion.

The authors begin by seeking to characterize how professionals view the hallmarks of aging, including genomic instability caused by DNA damage; alterations to the epigenome that controls which genes are turned on and off; loss of healthy protein maintenance, known as proteostasis; exhaustion of stem cells; and the production of inflammatory molecules.

"Address one of these, and you can slow down aging," the authors argue. "Address all of them, and you might not age."