Dr. David Sinclair

    From Longevity Wiki

    David Andrew Sinclair AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and is the co-director of its Paul F. Glenn Center for Biology of Aging Research. He is the president of the non-profit Academy for Health & Lifespan Research and an officer of the Order of Australia (AO).

    David is vegan since at least December 2021 [1].

    David Sinclair's Protocol

    Substance Dose When Comment
    Nicotinamide Mononucleotide (NMN) 1000 mg Morning
    Resveratrol 1000 mg Morning Started taking it in his early 30s[2]
    Metformin 800 mg Night, not when he making excercise the next day and muscles are growing
    Spermidine 1000 mg Morning
    Quercetin 500 mg Morning In [3] David mentoined that he took quercetin and fisetin around Jan 2022 for one month.
    Fisetin 500 mg Morning
    Vitamin D3 4,000 to 5,000 IUs
    Vitamin K2 180 to 360 mcg
    Vitamin Bs (B3, B6, B12) Variable Monitors Vitamin B levels with Inside Tracker because you want not too much and not too low
    Low-Dose Aspirin 83 mg Night
    Trimethylglycine (TMG) 500 - 1000 mg In a 2019 interview [4], David mentioned that he takes TMG as a precautionary measure, suggesting that excessive NMN supplementation might deplete the body's available methyl groups. However, only audio files of this interview remain, as the YouTube video was deleted. Notably, he hasn't mentioned TMG in any subsequent podcasts or videos, leading to the assumption that David might no longer be taking TMG.
    Alpha Lipoic Acid (ALA) Night
    Selenium By eating Brazil nuts
    Satin Takes Satin since he was 29 because his cholesterol was way up (beyond 300) and his grandmother had a stroke in her 30s.
    Coenzyme Q10 (coQ10) Night coQ10 is to make sure that the Satin doesn't deplete that too much
    Omega 3-6-9 (fish oil)
    Taurine 2000 mg

    References

    X = Taking, M = Taking in the morning, N = Taking at night, T = Taking temporarily
    NMN Reseratrol Metformin Berberine Spermidine Quercetin Fisetin Vitamin D3 Vitamin K2 Vitamin Bs Low-Dose Aspirin TMG ALA Statin coQ10 Omega 3-6-9 Selenium Magnesium GABA L-Theanin Taurine
    Lifespan: Why We Age – and Why We Don’t Have To Sept. 2019 X X X X X X
    2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging Dec 2021 X X M
    2022-01-26 - Podcast Dr. David Sinclair - NMN, NR, Resveratrol, Metformin & Other Longevity Molecules Jan 2022 X X N X X X
    2022-05-03 - Interview Dr. David Sinclair - Knowledge Project - How to Not Die May 2022
    2022-08-30 - Interview Dr. David Sinclair - Optimize Longevity - What To Eat & When For Longevity Aug 2022 X X X X X X N N X N X X
    2022-08-31 - Interview Dr. David Sinclair - Optimize Longevity - Longevity Molecules and Supplements Aug 2022 X X X X T T
    2022-09-02 - Interview Dr. David Sinclair - Optimize Longevity - Keeping Your Brain Young Sep 2022 X X X N N N
    2023-07-17 - Interview Dr. David Sinclair - Optimize Longevity - Build Muscle & Maintain Longevity Jul 2023 N X X

    Videos

    Produced by David Sinclair

    Podcasts

    Longevity Lifestyle Series with Serena Poon

    In August 2022 David Sinclair and Serena Poon startet the Optimize Longevity YouTube Channel that is all about tips for improving the quality of life and extending the lifespan.

    Season 1

    Season 2

    Season 3

    Interviews and Talks

    See also