Dr. David Sinclair

David Andrew Sinclair AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and is the co-director of its Paul F. Glenn Center for Biology of Aging Research. He is the president of the non-profit Academy for Health & Lifespan Research and an officer of the Order of Australia (AO).

David is vegan since at least December 2021 ^[1].

David Sinclair's Protocol


Substance	Dose	When	Comment
Nicotinamide Mononucleotide (NMN)	1000 mg	Morning
Resveratrol	1000 mg	Morning	Started taking it in his early 30s^[2]
Metformin	800 mg	Night, not when he making excercise the next day and muscles are growing
Spermidine	1000 mg	Morning
Quercetin	500 mg	Morning	In ^[3] David mentoined that he took quercetin and fisetin around Jan 2022 for one month.
Fisetin	500 mg	Morning
Vitamin D3	4,000 to 5,000 IUs
Vitamin K2	180 to 360 mcg
Vitamin Bs (B3, B6, B12)	Variable		Monitors Vitamin B levels with Inside Tracker because you want not too much and not too low
Low-Dose Aspirin	83 mg	Night
~~Trimethylglycine (TMG)~~	~~500 - 1000 mg~~		In a 2019 interview ^[4], David mentioned that he takes TMG as a precautionary measure, suggesting that excessive NMN supplementation might deplete the body's available methyl groups. However, only audio files of this interview remain, as the YouTube video was deleted. Notably, he hasn't mentioned TMG in any subsequent podcasts or videos, leading to the assumption that David might no longer be taking TMG.
Alpha Lipoic Acid (ALA)		Night
Selenium			By eating Brazil nuts
Satin			Takes Satin since he was 29 because his cholesterol was way up (beyond 300) and his grandmother had a stroke in her 30s.
Coenzyme Q10 (coQ10)		Night	coQ10 is to make sure that the Satin doesn't deplete that too much
Omega 3-6-9 (fish oil)
Taurine	2000 mg

References

X = Taking, M = Taking in the morning, N = Taking at night, T = Taking temporarily
		NMN	Reseratrol	Metformin	Berberine	Spermidine	Quercetin	Fisetin	Vitamin D3	Vitamin K2	Vitamin Bs	Low-Dose Aspirin	ALA	Statin	coQ10	Omega 3-6-9	Selenium	Magnesium	GABA	L-Theanin	Taurine
Lifespan: Why We Age – and Why We Don’t Have To	Sept. 2019	X	X	X					X	X		X
2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging	Dec 2021	X	X	M
2022-01-26 - Podcast Dr. David Sinclair - NMN, NR, Resveratrol, Metformin & Other Longevity Molecules	Jan 2022	X	X	N		X	X	X
2022-05-03 - Interview Dr. David Sinclair - Knowledge Project - How to Not Die	May 2022
2022-08-30 - Interview Dr. David Sinclair - Optimize Longevity - What To Eat & When For Longevity	Aug 2022	X	X	X					X	X	X	N	N	X	N	X	X
2022-08-31 - Interview Dr. David Sinclair - Optimize Longevity - Longevity Molecules and Supplements	Aug 2022	X	X	X		X	T	T
2022-09-02 - Interview Dr. David Sinclair - Optimize Longevity - Keeping Your Brain Young	Sep 2022												X		X	X		N	N	N
2023-07-17 - Interview Dr. David Sinclair - Optimize Longevity - Build Muscle & Maintain Longevity	Jul 2023			N	X																X

Videos

Produced by David Sinclair

Podcasts

Longevity Lifestyle Series with Serena Poon

In August 2022 David Sinclair and Serena Poon startet the Optimize Longevity YouTube Channel that is all about tips for improving the quality of life and extending the lifespan.

Season 1

Season 2

Season 3

2023-07-17 - Interview Dr. David Sinclair - Optimize Longevity - Build Muscle & Maintain Longevity