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Mice (Mus Musculus): Difference between revisions
→Mouse Strains Relevant for Longevity Research
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! Strain Name !! Description !! Key Traits !! Use in Longevity Research | ! Strain Name !! Description !! Key Traits !! Use in Longevity Research | ||
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| C57BL/6 || Most commonly used inbred strain || High susceptibility to diet-induced obesity || Often used as a reference strain in aging studies | | [[C57BL/6 mice|C57BL/6]] || Most commonly used inbred strain || High susceptibility to diet-induced obesity || Often used as a reference strain in aging studies | ||
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| Ames Dwarf || Mutant strain with deficiency in growth hormone, prolactin, and thyroid-stimulating hormone || Extended lifespan; reduced tumor incidence || Key model in studying hormonal effects on aging | | Ames Dwarf || Mutant strain with deficiency in growth hormone, prolactin, and thyroid-stimulating hormone || Extended lifespan; reduced tumor incidence || Key model in studying hormonal effects on aging | ||
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| SAM (Senescence-Accelerated Mouse) || Group of related strains with accelerated aging || Varies by substrain (e.g., SAMP8 shows early cognitive decline) || Widely used in aging research to study rapid aging effects | | SAM (Senescence-Accelerated Mouse) || Group of related strains with accelerated aging || Varies by substrain (e.g., SAMP8 shows early cognitive decline) || Widely used in aging research to study rapid aging effects | ||
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| ApoE−/− (Apolipoprotein E-deficient) || Mutant strain deficient in ApoE protein || Prone to cardiovascular diseases; develops atherosclerosis || Widely used in cardiovascular research, providing insights into age-related cardiovascular diseases | | [[ApoE−/− mice|ApoE−/−]] (Apolipoprotein E-deficient) || Mutant strain deficient in ApoE protein || Prone to cardiovascular diseases; develops atherosclerosis || Widely used in cardiovascular research, providing insights into age-related cardiovascular diseases | ||
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| C3H || Inbred strain with a propensity for certain tumors || Prone to mammary tumors; used in cancer research || Relevant in longevity research, especially in studies linking aging and cancer | | [[C3H mice|C3H]] || Inbred strain with a propensity for certain tumors || Prone to mammary tumors; used in cancer research || Relevant in longevity research, especially in studies linking aging and cancer | ||
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| B6C3F1 || Hybrid strain derived from C57BL/6 and C3H || High tumor incidence in old age || Used in carcinogenicity and aging studies | | B6C3F1 || Hybrid strain derived from C57BL/6 and C3H || High tumor incidence in old age || Used in carcinogenicity and aging studies | ||
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| DBA/2 || Inbred strain known for early age-related hearing loss || High bone density; resistant to diet-induced obesity || Used in sensory aging studies, particularly hearing | | DBA/2 || Inbred strain known for early age-related hearing loss || High bone density; resistant to diet-induced obesity || Used in sensory aging studies, particularly hearing | ||
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| BALB/c || Inbred strain with known susceptibility to certain cancers || High levels of anxiety-like behavior || Used in cancer and aging studies | | [[BALB/c mice|BALB/c]] || Inbred strain with known susceptibility to certain cancers || High levels of anxiety-like behavior || Used in cancer and aging studies | ||
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| ICR (Institute of Cancer Research) || Outbred strain || Good reproductive performance; used as general multipurpose strain || Often used as a control strain in various research, including aging | | ICR (Institute of Cancer Research) || Outbred strain || Good reproductive performance; used as general multipurpose strain || Often used as a control strain in various research, including aging | ||