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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 23:25, 5 November 2023
, 5 November 2023→Optimal Timing for Supplementation
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===Optimal Timing for Supplementation=== | ===Optimal Timing for Supplementation=== | ||
Our body has a natural rhythm where NAD+ levels fluctuate throughout the day rather than remaining constant, closely tied to our circadian rhythms.{{pmid|24051248}} | Our body has a natural rhythm where NAD+ levels fluctuate throughout the day rather than remaining constant, closely tied to our circadian rhythms.{{pmid|24051248}} NAD+ plays a crucial role in regulating our body's internal clock. The Sirt-1 gene, which is influenced by NAD+, signals our body when it's time to eat or sleep.{{pmid|32369735}} | ||
[[Dr. David Sinclair]] suggests to take NMN in the morning when the natural rise in NAD+ and [[SIRT1|Sirt-1]] activity should happen. Taking NMN e.g. at night might disrupt the NAD+ cycle and potentially affecting the sleep or hunger. This can be especially beneficial for frequent travelers trying to adjust to a new time zone, as a morning dose of NMN can help reset the body's internal clock and reduce jet lag. <ref>[[2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging]]</ref> | [[Dr. David Sinclair]] suggests to take NMN in the morning when the natural rise in NAD+ and [[SIRT1|Sirt-1]] activity should happen. Taking NMN e.g. at night might disrupt the NAD+ cycle and potentially affecting the sleep or hunger. This can be especially beneficial for frequent travelers trying to adjust to a new time zone, as a morning dose of NMN can help reset the body's internal clock and reduce jet lag. <ref>[[2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging]]</ref> | ||