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Methyl Donor Deficiency: Difference between revisions
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'''Methyl Donor Deficiency''' refers to a lack of certain nutrients in the body that provide [[Methyl Donors|methyl groups]], which are essential for many cellular functions. These functions include making DNA, creating certain fats in the body, and building proteins. Methyl groups come from what we eat, including nutrients like methionine, folate, betaine, and choline, which are found in various foods. | '''Methyl Donor Deficiency''' refers to a lack of certain nutrients in the body that provide [[Methyl Donors|methyl groups]], which are essential for many cellular functions. These functions include making DNA, creating certain fats in the body, and building proteins. Methyl groups come from what we eat, including nutrients like methionine, folate, betaine, and choline, which are found in various foods.{{pmid|24022817}} | ||
The body uses a substance called [[S-Adenosylmethionine (SAMe)]] to transfer methyl groups in many important reactions. SAMe is made from methionine, which we can get from our diet or from recycling a substance called homocysteine in our body. The liver and kidneys are especially good at storing betaine, which helps in this recycling process. However, if there's too much SAMe, it can actually slow down its own production by affecting other enzymes related to methyl group metabolism. | The body uses a substance called [[S-Adenosylmethionine (SAMe)]] to transfer methyl groups in many important reactions. SAMe is made from methionine, which we can get from our diet or from recycling a substance called homocysteine in our body. The liver and kidneys are especially good at storing betaine, which helps in this recycling process. However, if there's too much SAMe, it can actually slow down its own production by affecting other enzymes related to methyl group metabolism.{{pmid|24022817}} | ||
== Symptoms == | == Symptoms == | ||
Methyl donor deficiency can lead to a range of physiological and metabolic disturbances due to its impact on essential cellular functions, including DNA methylation, phosphatidylcholine synthesis, and protein synthesis. Below are some of the symptoms and consequences associated with this condition: | Methyl donor deficiency can lead to a range of physiological and metabolic disturbances due to its impact on essential cellular functions, including DNA methylation <ref>https://www.biocare.co.uk/news/10-signs-you-need-methylation-support.html</ref>, phosphatidylcholine synthesis, and protein synthesis. Below are some of the symptoms and consequences associated with this condition: | ||
=== Energy Metabolism and Muscle Disorders === | === Energy Metabolism and Muscle Disorders === | ||