Nicotinamide Mononucleotide (NMN): Difference between revisions

Nicotinamide Mononucleotide (NMN) (view source)

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 There is a theoretical concern that consuming NMN could deplete [[Methyl Donors|methyl groups]] in the body. This is because NMN is converted to NAD+ in the body, which can then be broken down into nicotinamide. Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which is excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body.
-There could be a compensatory mechanisms that if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, there is a potential concern is that excessive NMN supplementation might lead a [[Methyl Donor Deficiency]] to a decrease in the body's available methyl groups, which play crucial roles in various biological processes including DNA methylation and neurotransmitter synthesis.
+There could be a compensatory mechanisms that if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, there is a potential concern that excessive NMN supplementation might lead to a [[Methyl Donor Deficiency]] associated with low energy and tiredness, among other things.
 For that reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] like [[Trimethylglycine (TMG)]] to ensure that they are not depleting their body's methyl groups. However, this is a precautionary measure and not necessarily based on concrete evidence.
-However, there is '''no clear evidence yet'''. While the pathway is known, the actual significance of NMN supplementation on global methyl group status is not well-established in humans. It's a theoretical concern, and it would require substantial NMN consumption to have a significant impact as well as the comsumption of methyl donors in the diet would be too low to replenish methyl groups.
+However, there is '''no clear evidence yet'''. While the pathway is known, the actual significance of NMN supplementation on global methyl group status is not well-established in humans. It would require substantial NMN consumption to have a significant impact coupled with insufficient intake of dietary methyl donors to replenish these groups.
 ===Risks of NMN Supplementation===