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2022-08-31 - Interview Dr. David Sinclair - Optimize Longevity - Longevity Molecules and Supplements: Difference between revisions

2022-08-31 - Interview Dr. David Sinclair - Optimize Longevity - Longevity Molecules and Supplements (view source)

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(Created page with "* https://www.youtube.com/watch?v=qJydSIPxQMQ&t=2352s&ab_channel=OptimizeLongevity * Interviewer: Serena Poon * In Dr. David Sinclair’s fourth Lifespan Podcast episode, he n...")
 
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== Transcript ==
== Transcript ==
we've met people that eat terrible diets
=== Kicking Off Episode Four: Longevity Molecules ===
 
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and take a supplement thinking that that
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| - Welcome to the Lifespan podcast, where we discuss the science of aging and how to be healthier at any stage of life.
will replace a healthy diet and that's
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not true what we have shown in my lab
| I'm David Sinclair. I'm a professor at Harvard Medical School and Co-director of the Paul F. Glenn Center for Aging Research.
 
|-
and others many others have shown is
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| And I'm joined today by my lovely co-author and cohost, Matthew LaPlante.<br>- Hey, how are we doing?<br>- [David] Hey, welcome.
that
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you need to do both to get the biggest
| - Feeling good today.<br>- [Matthew] Back at it again.<br>- We are. We're here today to talk about how to live longer and better.
 
|-
bang for the buck and you can't just
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| - As part of this podcast series, this deep dive into things that you can do to slow, stop, and reverse aging.
expect supplements to replace a healthy
|-
 
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diet
| - That is true and today is going to be a really interesting one.<br>- This is going to be the one that everybody,
 
|-
[Music]
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| I mean, this is the one that everybody's been begging for.<br>- That is true. We've been monitoring the responses to tweets
hi
|-
 
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hi serena
| and Instagram posts, and most of them are, David, just tell us what to take.
 
|-
how are you
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| - [Matthew] The nice ones.<br>- Yeah.<br>- Some of those aren't very nice either, but yeah, please, please, please.
i'm great how are you doing i'm good so
|-
 
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i didn't do a big intro on you today
| Should I take NR? Should I take NMN? What should I do with Metformin? We're going to be talking about all of that today.
 
|-
because i figure by now it's our fourth
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| - We are, and our research team has been spending weeks on this, and if you can't see, I'm actually sitting in front of many pages of notes here.
part in our series and everybody knows
|-
 
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who you are
| We're going to go deep dive into what is fact and what is not fact. What is known, what is not known, because there's so much misinformation out there,
 
|-
um and if they don't then they can go
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| especially with supplements.<br>- Yeah. We do need to say we usually take a moment
back and watch our other three episodes
|-
 
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and learn all the things um but there
| to thank our sponsors, we're going to do that of course, but we also have to take a moment to say we are not medical doctors. We are not medical doctors.
 
|-
are so many questions and uh and it's
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| We are not medical doctors.<br>- What he said. I'm a PhD, I'm a researcher.
and it's wonderful because i finally
|-
 
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sort of had the chance to explain to
| I can read the literature. I've been doing it for the last 30 years. I distill that for everybody.
 
|-
everyone what these badges are that are
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| But of course, if you want to try supplement or even change your diet radically, please talk to your physician before you change anything.
down here and my team was trying to get
|-
 
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me to explain the last few episodes um
| Because some of the things we'll talk about today can affect your body in, hopefully, many good ways, but sometimes can be dangerous depending on the person.
 
|-
but what i was telling everyone is
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| And everybody's different.<br>- And what we want to do is give people the ability to have a more intelligent
you clearly are so busy you're on the
|-
 
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road now you're on the road all the time
| and informed conversation with their physician.<br>- Exactly.<br>- Okay, with that out of the way, now we should thank our sponsors.
 
|-
you're tuning in and doing this live to
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| - Let's do that, because this podcast is free to anybody who wants to watch or listen.
answer questions as a q a to the podcast
|}
 
=== Thanking the Sponsors ===
that you do every wednesday um and it's
{| style="padding-top: 1em;"
 
| style="min-width:4em; color: blue; text-align: right; padding-right: 1em; vertical-align: top;" | 2:15
just giving people an opportunity to ask
| Our first sponsor is Levels. Levels is an app that syncs with a continuous glucose monitor, which they provide,
 
|-
questions and we we try to house all the
| style="min-width:4em; color: blue; text-align: right; padding-right: 1em; vertical-align: top;" | 2:21
 
| and it interprets your glucose data for you. I've been so impressed by Levels that I've recently joined them as an advisor.
questions we can all the hundreds of
|-
 
| style="min-width:4em; color: blue; text-align: right; padding-right: 1em; vertical-align: top;" | 2:28
questions that come in every single week
| Monitoring your blood glucose allows you to see how different foods impact you. I've used Levels to see what foods impact me.
 
|-
we do the best we can to answer them but
| style="min-width:4em; color: blue; text-align: right; padding-right: 1em; vertical-align: top;" | 2:34
 
| I've learned that grapes spike my glucose, white rice, but actually potatoes aren't that bad.
it's so kind of you to do this and so
|-
 
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kind of both of our teams put in their
| It's not just interesting, it's also a lot of fun to see what's going on inside your body.
 
|-
energies to make this happen
| style="min-width:4em; color: blue; text-align: right; padding-right: 1em; vertical-align: top;" | 2:44
 
| So if you'd like to try Levels, you can skip the 150,000 person wait list. And you can join today by going to levels.link/sinclair.
but i was letting people know that these
|-
 
| style="min-width:4em; color: blue; text-align: right; padding-right: 1em; vertical-align: top;"
badges that are down here
 
is a way that they can show appreciation
 
to the team and also if they want to
 
bring a really important question up and
 
they want us to see it i guess the
 
badges highlight them in some way
 
uh so
 
so that was something that i wanted to
 
let everybody know and thank you for the
 
people that have literally just sent in
 
badges just as a thank you to the team
 
and to dr sinclair so so that's it i
 
know use up three minutes and we're
 
gonna go right into supplements so this
 
past episode you talked about it's like
 
a burning question everybody has which
 
are
 
what supplements do
 
or can we take for longevity what
 
molecules are important and today we'll
 
go over a handful of them that you talk
 
about so often not just in the podcast
 
drop the last podcast draft but um just
 
whenever you do talk so we're going to
 
talk a little bit about mmn nr what
 
those differences are nad
 
uh the differences between those three
 
things because most people don't really
 
understand um respiratory we're going to
 
talk about some synalytics uh quercetin
 
and
 
the seton and did you want to talk about
 
the satanism if we have time we'll talk
 
about that right yeah sounds good okay
 
and then um i met foreman berberine
 
spermidine
 
and for those of you guys that don't
 
know what spermadine is we're gonna get
 
really clear on what spermadine is so
 
there's no confusion at all um and then
 
probably some rapid myosin too so that's
 
what we're planning on covering today if
 
we don't cover everything then make a
 
note of it and we'll cover the parts
 
that we missed um in another episode
 
so okay
 
yeah
 
five dollars
 
yeah we're gonna try to pack it all in
 
all right i see lots of questions so
 
let's start with that let's start with
 
um the difference between nr enema and
 
energy i'm just gonna let you kind of go
 
uh while i scroll back and take a peek
 
at some of these questions okay great
 
um yeah so if you don't know nad is a
 
molecule that we need for life we have a
 
lot of it in our bodies we make less as
 
we get older and we destroy more as we
 
get older we need to
 
raise that back up
 
and so you typically if you're my age
 
i'm 52 now
 
i would have about half the levels that
 
i had when i was 20. so the idea is to
 
supplement and to get those levels back
 
up why because there are enzymes that
 
control longevity certains of the
 
enzymes we work on and they need nad so
 
do dna repair enzymes there's a protein
 
called parp1 that needs nad
 
and so what how do you raise an ad well
 
you can
 
uh fast you can exercise these are some
 
ways but you can also
 
complement
 
uh supplement that kind of a lifestyle
 
with supplements and
 
well you know i'll be very careful to
 
say when it's a mouse study versus a
 
human study we do know from some human
 
studies and a lot of male studies that
 
you can raise nad levels in the body so
 
let me tell you how to do that
 
well some people take nad now i don't
 
think that's the best way given what i
 
know about biology and cells because nad
 
is a very big molecule relative to these
 
other ones you've mentioned and it
 
doesn't get taken up into cells very
 
readily and probably what's happening in
 
the body is if you have an iv of nad
 
it's first broken down into its
 
constituents
 
which are what we've talked about but
 
it's the precursors and then rebuild
 
so if you're going to take it orally so
 
take a pill uh it can be sublingual can
 
be swallowed just as a powder or a
 
capsule i do the capsules every morning
 
with some water
 
what you want to do is is take a
 
precursor so how do you build nad what
 
does the cell do it needs various
 
components
 
nad stands for nicotinamide adenine
 
dinucleotide
 
and those are three components that you
 
need so the nicotinamide part of it you
 
can get as vitamin b3 but i don't
 
recommend to raise an ad levels by
 
taking vitamin b3 also known as niacin
 
or niacinamide or nicotinic acid this
 
this is just one part of a
 
big molecule we need to build so you
 
want to give all the components so what
 
are the other components there's the
 
adenine which is a sugary molecule
 
and then there's a phosphate which is
 
phosphorus which is oxygen and
 
phosphorus put together
 
so nicotinamide is vitamin b3 the sugar
 
is the adenine now those two put
 
together is nr
 
nicotinamide riboside so you've got two
 
out of three out of three components but
 
if you take an r you still need that
 
phosphate so phosphate where do you get
 
phosphate in the body well it's in your
 
bones it's in your dna
 
and your body needs to either take it
 
from the outside or bring it from from
 
your your bones or your dna so
 
the the other molecule that you
 
mentioned the one that i take
 
is nmn
 
nicotinamide
 
right vitamin b3
 
mononucleotide
 
which has the sugar in the middle
 
it's called a ribose and then the
 
phosphate is also on there and it's got
 
the three main components to make an ad
 
okay
 
and so what we find in our experiments
 
in mice and it seems true in humans
 
um though we do need some more research
 
is that if you take nmn
 
it raises nad
 
more readily to higher levels because
 
you've got all three of the components
 
to build nad whereas with nr you only
 
have two out of the three and if you
 
just take niacin or nicotinamide you've
 
got one out of the three
 
but it doesn't mean that if you take any
 
of those it won't help i just take nmn
 
because i think that it raises nad
 
levels the highest when you take it and
 
some people say do you need iv do you
 
need sublingual
 
how should you take it well what i've
 
done and with my colleagues at harvard
 
is test it in people and what happens is
 
if you take nmn over
 
a certain amount of time which is about
 
two weeks it'll steadily rise up to
 
about two
 
times the normal levels of what what i
 
would have
 
and so that's what i do but you don't
 
need to do anything fancy you just
 
swallow it and it seems to get in quite
 
fine into the body and raise those
 
energy levels and why do you do that
 
because we think that the body's natural
 
defenses against aging are heightened
 
like we're young again and in mice
 
there's lots of things that happen that
 
are good we see that mice run further
 
they have more activity they're better
 
metabolic control they're a bit leaner
 
and we and others see that older mice
 
are less frail now do we know this
 
happens in humans no we don't know but
 
we are doing those trials and there are
 
some studies already that show that
 
people have more endurance more oxygen
 
capacity which is what we see in mice as
 
well
 
so so thank you for that and that was
 
really helpful i know that we've
 
discussed it before and there are some
 
comments here about how we've talked
 
about anime before but i think it's
 
really important because this topic is
 
about supplements and something that i
 
actually wanted to
 
ask you to address was what is the
 
difference between drugs and supplements
 
and and right before you go into that
 
i'm just going to give our audience that
 
our amazing audience that's here we have
 
over 2 000 people just a reminder that
 
this is a this is a learning space and
 
it's a really kind space and for anyone
 
on here at the din can we speak of that
 
last episode
 
that isn't that didn't hear me speak
 
about this episode um we are going to
 
remove any unkind commentary that's on
 
here because it's very distracting to
 
the rest of our learning audience so
 
thank you so much and let's talk about
 
the difference between drugs and
 
supplements
 
right
 
um i do want to mention before i say
 
that that i take a gram of nmn a lot of
 
people ask me how much do i take it's a
 
gram a day not every day sometimes i
 
have a couple of days off we should talk
 
about on off days and timing um
 
okay but your question is drugs have
 
supplements well actually
 
they're the same thing
 
it's just that one's regulated and one
 
isn't in a different way i mean they're
 
both regulated but one is under the
 
fda's control and needs a prescription
 
in the u.s um and one doesn't and every
 
country has different rules but in
 
general
 
um the drugs like metformin that we're
 
going to talk about later you do need a
 
doctor's prescription and supplements
 
fall into a different category which are
 
classified as food and food-like
 
substances that you can buy over the
 
counter and that's really the main
 
difference it's important to remember
 
that a drug just because it's a drug
 
doesn't mean it's any different
 
some drugs are directly from plants or
 
just slight modifications metformin
 
which requires a prescription is derived
 
from a plant just slightly modified so
 
you just have to remember it's more
 
about regulation than actually
 
the substance itself
 
um so that's clarity on that and then
 
some people ask what a gram is a gram is
 
a thousand milligrams so any time we
 
kind of throw out uh measurements uh you
 
can always google to see what yeah how
 
much that is
 
uh for you in your metrics well there is
 
one more thing that i should mention
 
that's really important yeah
 
the the reason that the drugs are
 
also in a different category is that
 
they've gone through more testing
 
and that you can be less worried about
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