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Bioavailability: Difference between revisions
→Measuring Bioavailability
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=== '''Relative Bioavailability'''=== | === '''Relative Bioavailability'''=== | ||
Relative bioavailability compares the bioavailability of a drug in different formulations, typically against a standard or reference formulation. The formula is: | |||
:<math>F_{\text{rel}} = \frac{AUC_{\text{test}} \times Dose_{\text{ref}}}{AUC_{\text{ref}} \times Dose_{\text{test}}} \times 100\%</math> | :<math>F_{\text{rel}} = \frac{AUC_{\text{test}} \times Dose_{\text{ref}}}{AUC_{\text{ref}} \times Dose_{\text{test}}} \times 100\%</math> | ||
where AUC<sub>test</sub> and AUC<sub>ref</sub> are the [[Area Under the Curve (AUC)|areas under the curve]] for the test and reference formulations, respectively, and Dose is the dose for each. | where AUC<sub>test</sub> and AUC<sub>ref</sub> are the [[Area Under the Curve (AUC)|areas under the curve]] for the test and reference formulations, respectively, and Dose is the dose for each. | ||
==Improving Bioavailability== | ==Improving Bioavailability== | ||