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| == Transcript == | | == Transcript == |
| david welcome
| | === democratizing longevity === |
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| hey jason it's great to see you great to
| | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:00 |
| | | | david welcome hey jason it's great to see you great to have you back on the show and |
| have you back on the show and
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| | | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:06 |
| it was so awesome to see you mentioned
| | | it was so awesome to see you mentioned in our wellness trends specifically |
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| in our wellness trends specifically
| | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:11 |
| | | | around longevity and something we're particularly excited about and you're excited about is this |
| around longevity
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| | | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:18 |
| and something we're particularly excited
| | | idea of democracization you know when people tend to think of longevity |
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| about and you're excited about is this
| | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:23 |
| | | | they tend to think of really expensive tests and potential potentially pharmaceuticals and |
| idea of democracization
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| | | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:29 |
| you know
| | | supplements and so on they think of silicon valley and billionaires and all that crazy stuff you read |
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| when people tend to think of longevity
| | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:35 |
| | | | but let's take a step back and and talk about democratizing longevity and i'm curious you know what is democratizing |
| they tend to think of
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| | | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:42 |
| really expensive tests and potential
| | | longevity mean to you yeah well you're right that there is a group of |
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| potentially pharmaceuticals and
| | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:48 |
| | | | individuals that i meet more and more often that have the means and the wealth and |
| supplements and so on they think of
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| | | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:54 |
| silicon valley and billionaires and all
| | | the connections to extend their lifespan i think by 20 30 years |
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| that crazy stuff you read
| | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:00 |
| | | | but it's a small group of people and what we need to do is to give that that information |
| but let's take a step back and and talk
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| | | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:06 |
| about democratizing longevity and i'm
| | | to everybody and that involves not just making it available but truly being educational |
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| curious you know what is democratizing
| | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:12 |
| | | | and interesting and so what i've decided to do with my career as this harvard professor from a lab |
| longevity mean to you yeah well you're
| | |- |
| | | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:19 |
| right that there is a group of
| | | is to use hopefully decent abilities at storytelling to educate people and make |
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| individuals that
| | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:25 |
| | | | it interesting i have a podcast coming out early next year january 5th where |
| i meet more and more often
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| | | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:30 |
| that have the means and the wealth and
| | | hopefully it's an interesting uh journey through the longevity world of |
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| the connections
| | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:35 |
| | | | science and nutrition and and exercise but also supplements and |
| to extend their lifespan i think by
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| | | | style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:40 |
| 20 30 years
| | | some of the more far out things that these billionaires are into and so it's |
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| but it's a small group of people
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| and what we need to do is to give
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| that that information
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| to everybody and that involves not just
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| making it available but truly
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| being educational
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| and interesting and so what i've
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| decided to do with my career as this
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| harvard professor from a lab
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| is to use hopefully decent abilities at
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| storytelling to educate people and make
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| it interesting i have a podcast coming
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| out early next year january 5th where
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| hopefully it's an
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| interesting uh
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| journey through the longevity world of
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| science and
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| nutrition and and exercise but also
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| supplements and
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| some of the more far out things that
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| these billionaires are into and so it's
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| about education primarily but the second
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| part of that that i'm very into and
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| driven by is to make
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| the
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| medicines that will come out of this
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| field of aging research available to
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| everybody
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| uh because if it's just for the rich and
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| it's cost a hundred thousand dollars
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| treatment then that's really not going
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| to help me achieve my goal in life which
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| is to really make millions
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| hopefully billions of people live
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| healthier lives and in doing so lengthen
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| their life as well
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| and so the science that we do and the
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| drug developments on i've started about
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| a dozen companies now the companies are
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| very focused on making those drugs
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| are cheaply and widely available
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| and the kind of technologies for the
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| most part
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| are
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| drugs that could be just a few cents a
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| day once they
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| eventually uh get widely used
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| what do you think was the biggest update
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| that impacted our understanding
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| of longevity in the last year you're on
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| top of everything
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| what's been interesting to you over the
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| course of the last year
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| yeah
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| well
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| what's actually happening in society is
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| super interesting i used to be uh the
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| pariah of biology i'm so sure harvard
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| wanted to kick me out a few times
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| but there's been a real shift both in
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| mentality of doctors and researchers and
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| the public
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| that aging is something
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| that is more akin to a medical condition
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| a disease and that it's treatable so
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| there's this zeitgeist mega trend if you
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| want to call it in society that's
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| changed but in terms of research and
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| breakthroughs a really big one and
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| forgive me for focusing on myself for
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| one second my lab and the research team
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| and our collaborators a year ago exactly
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| to the day almost that
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| we could reset the body in terms of age
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| go back by about 80
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| and do a permanent reset of the body now
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| this is in animals but these are mice
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| that are very similar biologically to us
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| and we've done it now in human cells and
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| human
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| tissue so we're optimistic that the same
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| principles that i'm going to tell you
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| about in mice apply to humans and that
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| is that we have a backup copy of youth
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| in our bodies that can be accessed we're
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| now using gene therapy because that's
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| what we know works but we're hoping
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| uh to find natural molecules that will
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| achieve the same result to not just slow
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| down the aging process which we know we
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| can do by eating well at a training kind
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| of diet and exercising lose your breath
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| a few times a week at least
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| but by actually taking a supplement that
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| would reset the body within a matter of
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| a few months to go back
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| not just by six months but
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| many many years
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| and i truly believe that's going to be
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| possible in the next five to 10 years
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| and our goal now is as a society is to
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| stay alive until these discoveries
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| become mainstream
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| and so you you think we're five or so
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| years out from having that smart drug if
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| you will or
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| that
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| we can take and that alone will extend
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| health span
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| yeah i know it sounds crazy right
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| unfortunately i'm at harvard so people
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| tend to take me a little more seriously
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| but
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| the big
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| breakthrough was the discovery that we
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| have this backup copy
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| of
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| youthfulness
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| the easy part is figuring out how to
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| reset the system it's similar if you
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| want to use the analogy of the wright
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| brothers i know it's used a little too
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| much but it it works the wright brothers
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| the hard part was figuring out how to
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| glide around
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| the dunes strapping on the engine flying
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| eventually transcontinental flight now
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| global that's just extensions of what
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| they did in kitty hawk
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| and we basically in aging we've done
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| that now we know how to fly
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| and now we're going to strap on the
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| engine and see
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| how quickly and how cheaply we can do
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| this so i'm quite confident that we will
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| find molecules that will do this in fact
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| there was a paper that just came out
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| that shows a natural molecule called
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| alpha ketoglutarate
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| that i predicted in my book lifespan
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| probably would work
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| was able to reset the age
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| of 40 people i think out of 42 people 40
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| people had their biological age reversed
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| by an average of eight years
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| within just
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| uh under a year of taking this
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| supplement so akg
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| right and we can take that that is
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| currently a supplement that's out there
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| or can it be found in food naturally or
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| where can we find it i think a lot of
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| people are going to be very intrigued
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| yeah
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| me too like like most of these molecules
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| that plants make in response to stress
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| these molecules are called xenohermetins
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| that we name them that
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| they uh
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| you need to
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| a lot of them a lot of plants to get the
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| amounts that
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| are medicinal and so i it's better to
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| eat a purified source of it you can buy
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| akg or of ketoglutarate on the internet
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| i look for trust and supplier
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| very high quality high
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| content of alfie kimku right there are
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| some companies that are selling it that
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| are combinations with vitamins in the
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| case of this human study that's what
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| they sell but yeah it's widely available
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| and it would be really quite a thing for
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| humanity to have a safe molecule that's
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| similar to an amino acid that we could
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| just pop and if it's true take our years
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| our age back by half a decade or a
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| decade now i'm quite skeptical because
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| it sounds way too good to be true
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| but then again some things are true so
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| we're going to repeat the experiment
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| and see what happens but i will say that
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| the reason i think it's it's plausible
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| is that if you give alpha ketoglutarate
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| to yeast cells that make beer and bread
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| to fruit flies and to mice they also
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| live longer so there's something really
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| important going on here
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| building off of akg
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| resveratrol you've always been a fan of
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| resveratrol in many ways i feel like you
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| put resveratrol on the map are you still
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| a fan of resveratrol in terms of
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| supplementation and in terms of some of
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| the magic can do in terms of our
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| longevity
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| well i i am since we first made this
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| discovery in 2003
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| or there are something like 5 000 papers
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| showing that it's beneficial to cells
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| human cells and animal studies and and
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| even now there's about a dozen
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| positive human studies with resveratrol
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| now the downside of resveratrol is that
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| you cannot get it from red wine you'd
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| need to drink 200 glasses a day and that
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| even when you buy it purified
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| it's it's insoluble so if you put a
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| spoonful of resveratrol which i did take
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| every morning into water it'll sink to
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| the bottom
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| so you need to mix it with something i i
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| have a low-fat yogurt i recently am
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| doing vegan yogurts
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| which work well coconut base or with a
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| bit of olive oil which
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