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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 04:15, 16 November 2023
, 16 November 2023→Methyl Donor Deficiency
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* Nausea | * Nausea | ||
* Headaches | * Headaches | ||
* Low energy and tiredness (potentially caused by [[Methyl Donor Deficiency|methyl donor deficiency]])<ref>https://renuebyscience.com/forums/viewtopic.php?t=2575</ref> | * Low energy and tiredness (potentially caused by [[Methyl Donor Deficiency|methyl donor deficiency]])<ref name=":0">https://renuebyscience.com/forums/viewtopic.php?t=2575</ref> | ||
It is important to monitor for any adverse reactions, especially when starting supplementation or changing dosages. | It is important to monitor for any adverse reactions, especially when starting supplementation or changing dosages. | ||
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There is a theoretical concern that consuming NMN could deplete [[Methyl Donors|methyl groups]] in the body and might lead to a [[Methyl Donor Deficiency]] associated with symptoms such as low energy and tiredness. NMN is converted to NAD+ in the body, which can then be broken down into nicotinamide. Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which is excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body. | There is a theoretical concern that consuming NMN could deplete [[Methyl Donors|methyl groups]] in the body and might lead to a [[Methyl Donor Deficiency]] associated with symptoms such as low energy and tiredness. NMN is converted to NAD+ in the body, which can then be broken down into nicotinamide. Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which is excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body. | ||
For this reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] such as [[Trimethylglycine (TMG)]] or [[Vitamin B Complex]] to ensure that they are not depleting their body's supply of methyl groups. Some individuals take methyl donors as a precautionary measure, while others may begin supplementation after experiencing sleepiness attributed to NMN.<ref | For this reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] such as [[Trimethylglycine (TMG)]] or [[Vitamin B Complex]] to ensure that they are not depleting their body's supply of methyl groups. Some individuals take methyl donors as a precautionary measure, while others may begin supplementation after experiencing sleepiness attributed to NMN.<ref name=":0" /> | ||
However, there is no clear evidence yet as clinical trials are lacking. While the biochemical pathway is known, the actual impact of NMN supplementation on the global status of methyl groups is not well-established in humans. It would likely require substantial NMN consumption coupled with an insufficient intake of dietary methyl donors to significantly affect these groups. There could be also a compensatory mechanisms in place slowing down the conversion of NMN to NAD+ or the methylation of nicotinamide if methyl groups were being depleted. | However, there is no clear evidence yet as clinical trials are lacking. While the biochemical pathway is known, the actual impact of NMN supplementation on the global status of methyl groups is not well-established in humans. It would likely require substantial NMN consumption coupled with an insufficient intake of dietary methyl donors to significantly affect these groups. There could be also a compensatory mechanisms in place slowing down the conversion of NMN to NAD+ or the methylation of nicotinamide if methyl groups were being depleted. | ||