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2023-03-18 - Interview Dr. David Sinclair - India Today - Exclusive Conversation With Geneticist & Harvard Professor David Sinclair: Difference between revisions

2023-03-18 - Interview Dr. David Sinclair - India Today - Exclusive Conversation With Geneticist & Harvard Professor David Sinclair (view source)

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== Transcript ==
== Transcript ==
good afternoon everyone
=== Introduction ===
 
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we're fast coming to an Era where we
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| good afternoon everyone we're fast coming to an Era where we
will be celebrating our DNA age and not
|-
 
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our birth age
| will be celebrating our DNA age and not our birth age our birthdays will mean we get younger
 
|-
our birthdays will mean we get younger
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| and not older imagine that I have with me
and not older imagine that
|-
 
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I have with me
| the handsome Miracle almost 54 year old doctor from Howard Middle medical school
 
|-
the handsome Miracle almost 54 year old
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| who specialized in molecular genetics
doctor from Howard Middle medical school
|-
 
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who specialized in molecular genetics
| he promises no aging no wrinkles no disease and possibly choosing your own
 
|-
he promises no aging no wrinkles no
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| death date author of lifespan and professor of
disease and possibly choosing your own
|-
 
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death date
| genetics welcome there are many beautiful people here today in the audience but Everyone
 
|-
author of lifespan and professor of
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| likes a few tips right so first of all can you explain to the
genetics
|-
 
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welcome there are many beautiful people
| audience here what is the basic theory of reversing aging and bio switches
 
|-
here today in the audience but Everyone
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| well thank you Kali thank you for having me today uh so the science of aging and aging
likes a few tips right
|-
 
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so first of all can you explain to the
| reversal has come a long way in the past 20 years uh when I started at Harvard Medical School it was considered crazy to try
 
|-
audience here what is the basic theory
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| and slow down aging let alone reverse it but the science is now at a point where
of
|-
 
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reversing aging and bio switches
| we really do understand what drives aging and also that there's a backup copy of Youth in every one of
 
|-
well thank you Kali thank you for having
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| our many trillions of cells that we've just recently learned how to access and
me today
|-
 
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uh so the science of aging and aging
| reboot the body like you would reboot an old computer and reinstate the youthfulness of
 
|-
reversal has come a long way in the past
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| tissues and organs and make them work again like they were young and this is only a few
20 years
|-
 
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uh when I started at Harvard Medical
| years old now but it's the technology is far beyond what I thought I would see in my lifetime and it's only getting faster
 
|-
School it was considered crazy to try
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and slow down aging let alone reverse it
 
but the science is now at a point where
 
we really do understand
 
what drives aging and also that there's
 
a backup copy of Youth in every one of
 
our many trillions of cells that we've
 
just recently learned how to access and
 
reboot the body like you would reboot an
 
old computer
 
and reinstate the youthfulness of
 
tissues
 
and organs and make them work again like
 
they were young and this is only a few
 
years old now but it's the technology is
 
far beyond what I thought I would see in
 
my lifetime and it's only getting faster
 
in its development
 
so can you explain the basic Theory
 
which is about keeping the body under a
 
state of constant stress to activate the
 
longevity genes how does that work
 
Yeah you mentioned the bio switches what
 
we discovered in my lab and in many labs
 
around the world
 
that is that there are genes that
 
control how long we live
 
some of us are born with
 
the best versions of those genes and
 
those people tend to live over a hundred
 
those with parents like the Prime
 
Minister that lived over 100 I tend to
 
live also for a long time but most of us
 
are not born with the perfect set of
 
genes so we need to do a little extra
 
and what we've discovered is that how we
 
live our life what we eat how much we
 
move the type of molecules that we
 
ingest every day how we sleep how
 
relaxed we are how many friends we have
 
this modifies another type of system in
 
the body
 
that's called the epigenome the
 
epigenome is different from the genome
 
I think you all know that the genome is
 
the DNA that we get from our parents the
 
epigenome is what controls the DNA that
 
tells a brain cell to be different from
 
a liver cell from a toenail producing
 
cell
 
and over time we lose those instructions
 
the epigenetic instructions
 
become lost
 
and what we've found is that by living a
 
healthy life
 
the kind of life that we'll talk about
 
later you can slow that rate of Aging
 
and prevent this this Corruption of the
 
body software
 
and even reboot it
 
so can we talk a little bit about this
 
style of living what are the things that
 
we can do to slow that aging process
 
down and activate these genes
 
yeah well there's there's some good and
 
bad news the good news is that aging is
 
much easier to slow and reverse than we
 
thought
 
the bad news is that what causes us to
 
slow our aging process is to give our
 
bodies a bit of a shock
 
in today's lifestyle most of us have an
 
abundance many of us we have enough food
 
and we don't need to exercise
 
that's not the way we used to live and
 
it's not the way our bodies perform the
 
best
 
by sitting for most of our lives and
 
eating almost you know constantly three
 
meals a day for many of us we end up
 
turning off these body switches and the
 
body ages faster and faster so we've
 
built a world that's very comfortable
 
but the backlash is that we age faster
 
so what we've discovered in my lab in
 
studies in yeast cells that make bread
 
and beer in worms and flies and mice and
 
monkeys and now humans is that we want
 
to put our bodies into a state of
 
adversity make the body feel a little
 
bit uncomfortable so how do we do that
 
well we can skip meals we can exercise
 
we can eat food that it's that is
 
plucked from the ground when it's also
 
stressed because they have wonderful
 
chemicals in them that make us healthier
 
and we can also get enough rest and calm
 
down the sleep that leads to
 
inflammation and other things like that
 
so really you want to make your body
 
fearful of running out of food or
 
fearful that you're having to run away
 
from a from a tiger and that turns on
 
the body's defenses against aging we've
 
learned but that doesn't reverse aging
 
so much that's requires a little bit
 
more attention which we've only recently
 
figured out how to control
 
and before
 
can we talk a little bit about skipping
 
meals what what do you recommend as a
 
diet
 
for slowing down the aging process
 
there is a set of genes that I wrote
 
about in my book lifespan that's called
 
the sirtuins and they get turned on when
 
there's not enough energy in the body so
 
if you don't have a lot of sugar in your
 
bloodstream or a lot of protein they
 
will get turned on and they defend the
 
body against the damage that causes the
 
the aging process and so what I've over
 
time learned to do is to skip meals I'm
 
not always successful
 
sometimes I have breakfast in in uh in
 
beautiful places but from my my goal is
 
to not eat a large meal until dinner
 
and then I eat a very healthy vegan meal
 
uh and very rarely alcohol and this diet
 
that I have gone on to for now about 18
 
months my partner Serena poon who's a
 
nutritionist and a longevity expert as
 
well
 
moved me from what I thought was a
 
healthy diet Mediterranean diet with
 
some red wine and cheese I went
 
completely to mostly well almost
 
completely to plants and my body has
 
responded I look better I think my skin
 
is better I feel better my memory is
 
certainly better
 
but I think it's not just what you eat
 
it's also when you eat and this constant
 
eating three meals a day plus snacks is
 
making us age faster than we need to
 
so are you recommending intermittent
 
fasting
 
well the way we put it Serena and I is
 
you want to eat within a certain window
 
and so I like to eat within a period of
 
about six hours a day and not more I can
 
snack you know some snacks might be some
 
sugar-free chocolate or some nuts or
 
some avocado it's not a crime to eat if
 
you're a little bit hungry but don't eat
 
a big meal and if you can until either
 
late at night or or have it in the
 
morning because you want to have a
 
period where your body is not ingesting
 
food and it will turn on its defenses
 
against disease and aging see can you
 
talk a little bit about the fact when
 
you went almost 20 hours without eating
 
and you did that for a period of time
 
yeah so 20 hours is a long time to go
 
without food every day but your body
 
gets used to it I found that after two
 
weeks of doing that I was not hungry
 
anymore if I felt a little bit hungry I
 
would drink a lot of tea Serena and I
 
have a green tea matcha which is filled
 
with all these wonderful chemicals from
 
stress plants
 
and drink drink a lot of water and tea I
 
think here in India we know how to do
 
that
 
and that is the solution and
 
we often think oh we
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