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2023-06-26 - Interview Dr. David Sinclair - The Longevity Experts - Why We Don't Have to Age & How to Fight Aging: Difference between revisions

2023-06-26 - Interview Dr. David Sinclair - The Longevity Experts - Why We Don't Have to Age & How to Fight Aging (view source)

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== Transcript ==
== Transcript ==
thank you
=== Intro ===
 
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| thank you [Music]
I've heard you say that there's no
|-
 
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biological law that says we have to age
| I've heard you say that there's no biological law that says we have to age which is which is a pretty radical
 
|-
which is which is a pretty radical
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| statement break that down for us a bit we tend to think that what we see is inevitable and it used to be the case
statement break that down for us a bit
|-
 
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we tend to think that what we see is
| for the speed of humans on the planet we used to think that horseback was the fastest humans could
 
|-
inevitable and it used to be the case
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| go we used to think that when you got an infection from a splinter that went gangrenous that was the end of that limb
for the speed of humans on the planet we
|-
 
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used to think that
| or death we used to think that childbirth was always going to be potentially lethal uh these things we we
 
|-
horseback was the fastest humans could
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| used to think were inevitable now we're in a world where I'm trying to let the world know that aging is no longer
go we used to think that when you got an
|-
 
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infection from a splinter that went
| inevitable um and in I'm a biologist I'm a geneticist at Harvard where I've been
 
|-
gangrenous that was the end of that limb
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| studying this for close to 30 years now and there's been no evidence from my lab
or death we used to think that
|-
 
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childbirth was always going to be
| or any lab around the world that has found evidence of any mechanism that tells us
 
|-
potentially lethal uh these things we we
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| that we must age there are processes that we've identified that happen over time but we found that those are highly
used to think were inevitable now we're
|-
 
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in a world where I'm trying to let the
| malleable we can slow them down and even in the last few years almost completely completely reset the system and reverse
 
|-
world know that aging is no longer
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| aging and so I I challenge anyone to correct me when I say that aging is not
inevitable
|-
 
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um and in I'm a biologist I'm a
| inevitable and also that there is a limit to human
 
|-
geneticist at Harvard where I've been
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| lifespan where's the evidence for that there are plenty of species that live a lot longer than we do and genetically
studying this for close to 30 years now
|-
 
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and there's been no evidence from my lab
 
or any lab around the world that has
 
found
 
evidence of any mechanism that tells us
 
that we must age there are processes
 
that we've identified that happen over
 
time but we found that those are highly
 
malleable we can slow them down and even
 
in the last few years almost completely
 
completely reset the system and reverse
 
aging and so I I challenge anyone to
 
correct me when I say that aging is not
 
inevitable
 
and also that there is a limit to human
 
lifespan where's the evidence for that
 
there are plenty of species that live a
 
lot longer than we do and genetically
 
they're not that different from us
 
and with the technology that we have
 
today like let's say we stop developing
 
technology today what do you think the
 
upper limit is of how long people can
 
live
 
well with today's technology uh if you
 
have the means I actually think we're
 
pretty close to being able to prevent
 
most cancers and heart disease and
 
diabetes so those major killers are
 
already largely preventable and I'm
 
including things like DNA tests for
 
cancer and MRI scans so yeah not
 
everyone can afford those yet but
 
shortly they hopefully will be able to
 
so if we stop technology right now I
 
think that
 
with a good diet and that knowledge and
 
lifestyle
 
the average person could probably make
 
it to 95. you know there are plenty
 
people who don't have the the knowledge
 
or the means to do the right thing and
 
that's one of the things that I'm doing
 
is education but I think that we're
 
about to completely blow past human uh
 
longevity expectations and history of
 
longevity so right now people who don't
 
look after themselves bring the average
 
down there's covert there's drug
 
addiction uh that brings the average
 
down across the planet especially in the
 
US and so the average is almost 80 years
 
old here but those people who
 
um look after their bodies from an early
 
age and do the right things and live
 
long enough to to be able to reap the
 
benefits of today's technology
 
um not even the future ones
 
um can expect to live into their 90s my
 
father looked after himself late in life
 
and he's now 84 and as healthy as he's
 
ever been in his whole life so these are
 
the this is what people can expect now
 
even with today's knowledge and
 
technology
 
and where do you think like where where
 
you said we're kind of like at the point
 
we're hitting some of these
 
breakthroughs what are the big
 
breakthroughs that have to happen to go
 
from let's say people living into their
 
90s to people living into their 150s
 
well they're happening in real time
 
actually uh every week there's another
 
breakthrough in aging research it's it
 
was a slow field when I started in yeast
 
cells we were excited to make a yeast
 
Cell live 30 longer that's 1995
 
technology
 
uh things are happening at a rapid Pace
 
we've got the discovery that there's a
 
backup copy of Youth in every cell in
 
the body that can be tapped into where
 
curing my lab and companies that I've
 
started and others that are competing
 
with mine or at least uh friendly
 
competition uh are showing that that
 
it's not that difficult to reverse the
 
age of an animal
 
um we've done this in mice many times
 
now it's not that difficult a high
 
school student could do it with the
 
knowledge that we have now
 
um we're at the point where we're
 
awaiting uh next week we'll announce
 
results in monkeys for age reversal
 
we're curing blindness using this
 
technology out of my lab so we you know
 
I would say that the Wright brothers are
 
flying already do we have Commercial Air
 
flight do we have a Concord yet no but
 
we know it's possible to fly so it's
 
really not a question of of uh if
 
anymore it's just a question of when
 
these Technologies become widely
 
available
 
so what's gonna what has to happen we
 
need to figure out a safe way to
 
reprogram tissues in the body and
 
eventually the whole body uh
 
we already have done some clinical
 
trials in my companies we have positive
 
human data that shows that we can slow
 
down and reverse some aspects of Aging
 
biochemistry and the body can be
 
reversed such as cholesterol levels
 
blood pressure these are all doable with
 
today's technology out of my lab there's
 
a new technology which is even better
 
than that which is a little a little bit
 
behind that we haven't gone into humans
 
but we are in monkeys as I mentioned
 
that in the next two years will treat
 
our first patient it'll be uh to cure
 
blindness
 
um and so you know the answer really is
 
that I think we've already made a lot of
 
the breakthroughs that can extend human
 
lifespan by decades
 
um getting to 150 I don't think those
 
breakthroughs are that far away given
 
how fast the field is going right now
 
the investment in the billions of
 
dollars into not just Labs but in
 
particular industry that has virgin just
 
since our paper in 2020 showing that age
 
reversal is safe age reversal is
 
possible
 
so I'm I'm 49 and let's say relatively
 
healthy like what what what's a
 
prediction and have have some money I
 
can spend on some of these things what's
 
a prediction for the average person like
 
me like how how long is somebody like me
 
going to live do you think yeah I think
 
you need to throw away any uh
 
preconceived ideas by looking at your
 
parents and certainly your grandparents
 
uh we are going to live very different
 
lives we're actually approaching a big
 
inflection point for those who are alive
 
when these Technologies come on board in
 
the next decade
 
um so the point is if you know you're
 
young uh or but some people who are in
 
their 70s 80s and 90s
 
you got to stick around do your best to
 
live as healthy as possible seek the
 
best medical care
 
uh get scanned if you if you want to
 
detect cancer invest in your health is
 
the point you know you can invest in
 
coffee every morning from a certain
 
store down the road or you can invest
 
that same money and afford an MRI scan
 
for cancer so stay alive for yourself at
 
your age uh things are going to happen
 
 
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