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2023-08-24 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Aging is Now Optional (Abundance360): Difference between revisions

2023-08-24 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Aging is Now Optional (Abundance360) (view source)

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== Transcript ==
== Transcript ==
do you think there is an upper limit to
=== Unlocking the Secret to Longevity ===
 
{| style="padding-top: 1em;"
human aging it's not even a question
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| do you think there is an upper limit to human aging it's not even a question
explain
|-
 
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[Music]
| explain [Music] I thought that that wasn't fair to have
 
|-
I thought that that wasn't fair to have
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| Consciousness and to know that we're going to be sick and die and watch everyone else died I was inspired by my grandmother who told me that humans can
Consciousness and to know that we're
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:20
going to be sick and die and watch
| do better my PhD supervisor said why would you go study aging it's not even a real science and thank goodness I didn't
 
|-
everyone else died I was inspired by my
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:26
 
| listen to him aging isn't just damage to the body like we wear out it's actually a loss of information there will be a
grandmother who told me that humans can
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:33
do better my PhD supervisor said why
| day I believe where you'll be able to rejuvenate your brain and get back memories get your ability to learn again I'm no longer talking about slowing
 
|-
would you go study aging it's not even a
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:40
 
| aging I'm talking about true age reversal multiple times there's a backup copy of information in every cell and
real science and thank goodness I didn't
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:47
listen to him aging isn't just damage to
| that fact that there was a backup copy changes everything there is no law that
 
|-
the body like we wear out it's actually
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:52
 
| says we must age remember that foreign [Music]
a loss of information there will be a
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:58
day I believe where you'll be able to
| welcome to moonshots and mindsets one of my favorite conversations from abundance 360 this year was a fireside chat with
 
|-
rejuvenate your brain and get back
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| Dr David Sinclair knowing around the world as one of the leading if not the leading thinker on age reversal and
memories get your ability to learn again
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:13
I'm no longer talking about slowing
| epigenetics David is a professor at Harvard Medical School who studies aging
 
|-
aging I'm talking about true age
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:18
 
| and Longevity he had just published a epic paper in cell about the work he's
reversal multiple times there's a backup
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:24
copy of information in every cell and
| done over 13 years on how to accelerate aging from epigenetic changes and then
 
|-
that fact that there was a backup copy
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:30
 
| reverse that aging in this segment we're going to be diving into the work that he's most recently done and where he
changes everything there is no law that
|-
 
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says we must age remember that
| thinks it's going you know uh I'm a fan of David a big fan
 
|-
foreign
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| I've donated to his lab I've written about his work in the book that I wrote with Tony Robbins called uh life force I
[Music]
|-
 
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welcome to moonshots and mindsets one of
| promoted his book lifespan David Sinclair's book uh probably more than I've promoted my books he's one of the
 
|-
my favorite conversations from abundance
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:57
 
| most exhilarating thinkers a dear and Beautiful Soul we're going to be
360 this year was a fireside chat with
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 2:02
Dr David Sinclair knowing around the
| visiting David during my longevity Platinum trip this coming August and going to his lab and I'll probably have
 
|-
world as one of the leading if not the
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 2:09
 
| a follow-on podcast when we dive into some of the deep science that
leading thinker on age reversal and
 
epigenetics David is a professor at
 
Harvard Medical School who studies aging
 
and Longevity he had just published a
 
epic paper in cell about the work he's
 
done over 13 years on how to accelerate
 
aging from epigenetic changes and then
 
reverse that aging in this segment we're
 
going to be diving into the work that
 
he's most recently done and where he
 
thinks it's going
 
you know uh I'm a fan of David a big fan
 
I've donated to his lab I've written
 
about his work in the book that I wrote
 
with Tony Robbins called uh life force I
 
promoted his book lifespan David
 
Sinclair's book uh probably more than
 
I've promoted my books he's one of the
 
most exhilarating thinkers a dear and
 
Beautiful Soul we're going to be
 
visiting David during my longevity
 
Platinum trip this coming August and
 
going to his lab and I'll probably have
 
a follow-on podcast when we dive into
 
some of the deep science that he's doing
 
he's an individual that during this
 
conversation will answer the question is
 
there an upper age to how long we live
 
what is the latest on the epigenetic
 
reprogramming that has been able to
 
reverse the aging of tissues and he's
 
someone with whom I'm working on a
 
health span X prize super excited about
 
this all right so settle in get ready
 
what would you do with an extra 20 or 30
 
years of a healthy lifespan
 
you're about to find out enjoy this
 
episode from my private Summit abundance
 
360 with Dr David Sinclair welcome David
 
thanks Peter thanks for having me back
 
hi everyone
 
um uh thank you to you and Serena for
 
flying in from India it was a long
 
flight how long was that
 
I don't know
 
too long
 
uh well uh the topic of longevity has
 
grown to uh one of Epic Proportions
 
um and I think I want to hit on the
 
point I made earlier uh the idea of
 
human health span extension of age
 
reversal was kind of a taboo subject a
 
while ago wasn't it
 
well not too long ago yeah when I
 
started in this field in the early 90s
 
it was considered the end of my career
 
by many people so my PhD supervisor said
 
why would you go study aging it's too
 
complicated to understand it's not even
 
a real science and thank goodness I
 
didn't listen to him yeah
 
so remember that for our students out
 
there watching
 
was it what what was it that got you
 
um to move into that direction was it a
 
personal passion was it an Inkling
 
I was definitely more than an inkling
 
and still is uh if any of you have read
 
my book you'll know that it was um by
 
the way how many folks up here have read
 
lifespan yes thank you I appreciate that
 
um
 
and Peter I think you know the answer to
 
the question that's why you asked it I
 
uh
 
I was inspired by my grandmother who
 
told me that humans can do better and
 
that's what I love about what Peter does
 
here it's that's the vision it's that we
 
can always do better there's a Bright
 
Horizon that we need to get to we need
 
to steer Humanity in that direction
 
um I felt that way my whole life that's
 
why we're friends uh among other reasons
 
and uh so she said when I was four years
 
old that everybody I knew in including
 
my pets uh were gonna die and it's not
 
going to be pretty
 
um and then I'm gonna die and as a
 
four-year-old that was a bit of a shock
 
to be told that and we all we all learn
 
this around the same age but we forget
 
about it because it's too painful to
 
live every day knowing that fact as
 
sentient beings as conscious animals
 
it's really a burden that we we bear
 
and I also I thought that that wasn't
 
fair to have Consciousness and to know
 
that we're going to be sick and die and
 
watch everyone else die
 
that was the age four and then at age
 
around 15 16 I thought this new
 
technology called genetic engineering
 
could actually tackle this problem in a
 
way that had never been done before so I
 
set my sights on that
 
let's go to uh January 12th uh you
 
published a paper and sell you published
 
a few Landmark papers this one being
 
amongst them
 
that showed
 
the ability to control aging using
 
epigenetics in mammals
 
just you know what were the major points
 
of that paper because it definitely it
 
cemented your your work and this this
 
concept of the information a Theory of
 
Aging
 
yeah so the information Theory of Aging
 
as it's called
 
um I formulated when I was still in my
 
20s I woke up in the middle of the night
 
with this idea it I guess it was
 
delivered to me by Muse's I wrote it
 
down in in my notebook and I still have
 
that notebook in my office and I've been
 
going off that Playbook ever since and
 
that's the idea that aging isn't just
 
damage to the body like we wear out it's
 
actually a loss of information that we
 
inherited uh from our parents and built
 
on during development
 
and ye cells have that problem and we
 
just finally published when was that 25
 
years later that we mammals have the
 
same issue and by understanding I think
 
a large part of why we age we're able to
 
control the aging process in a colony of
 
mice driving them forwards and backwards
 
in their age and making them get
 
diseases
 
um and now we're even reversing those
 
that's spectacular so one of the
 
questions we asked everybody when they
 
walked in here was to put on their badge
 
how old do you think you will live
 
and uh you know I think the 90 had had
 
120 or higher but I think what's
 
happened to society has trained us to
 
have certain expectations right you know
 
if your parents or grandparents had made
 
it to 75 or 80 you expect that and when
 
you hear the oldest living human being
 
is 122 123 you think okay there's a
 
brick wall there
 
um I one of the questions I'd love you
 
to share when the answer to let you
 
share is do you think there is an upper
 
limit to human aging
 
well I know there isn't you know there
 
is not yeah yeah it's not even a
 
question
 
drop the mic moment
 
let me explain
 
uh that there are lots of reasons why I
 
give that answer to me it's self-evident
 
but uh for some people it isn't and
 
there are critics of this idea that we
 
can live beyond 120 but one of the best
 
examples is
 
uh that we've been able to extend the
 
lifespan of every species that we've
 
tried to extend the lifespan of and
 
we're no different from those species
 
that's point one
 
um the second is that there are many
 
species who are very similar to us
 
genetically biologically that live a lot
 
longer than we do uh the best example
 
would be the bowhead whale but a lot of
 
whales live longer than us and that you
 
know they have children they're
 
conscious they produce milk so we just
 
need to mimic what they have that allows
 
them to live so long and I think we have
 
a much better idea now of how to do that
 
and so yeah that there is no law that
 
says we must age remember that
 
so one of the things that's going on
 
we've spent the last few days talking
 
about uh massive advances in Ai and
 
Quantum Computing and sensors networks
 
big data and the realization is we're in
 
a period of very hyper growth of these
 
Technologies and
 
um you know as Ray Kurzweil who will be
 
speaking tomorrow morning talks about
 
the bridge to a bridge that your job is
 
not to live
 
now to do something that's going to get
 
you an extra 100 years it's to get you
 
the next 10 healthy years to intercept
 
those Technologies do you agree with the
 
idea David I think you do but maybe your
 
time frame is different that this next
 
decade is very different than any time
 
ever
 
oh for sure
 
uh so we're already many decades ahead
 
of where I thought we would be
 
technologically
 
um from when I started I thought I was
 
working to help my children and future
 
children and uh and grandchildren but it
 
turns out that the pace of Discovery has
 
gone way faster and that's partly due to
 
technology we can now do an experiment
 
that analyzes billions of genes in the
 
same time frame
 
in a day that used to take us years of
 
work and billions of dollars and that
 
allows us
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