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Isoleucine: Difference between revisions
→Isoleucine Restriction
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=== Isoleucine Restriction === | === Isoleucine Restriction === | ||
[[File:isoleucine Restriction in UM-HET3 mice.jpg|thumb|Isoleucine restriction in UM-HET3 mice]] | |||
Isoleucine restriction (IleR) has been identified as a significant factor in improving metabolic health and extending lifespan, particularly in genetically heterogeneous UM-HET3 mice. Restricting dietary isoleucine by 67% promotes leanness and glycemic control in both sexes, while also reprogramming hepatic metabolism in a sex-specific manner. Notably, IleR has been observed to reduce frailty and increase the lifespan by 33% of both male and female mice, with more pronounced effects in males. These findings suggest that IleR, or pharmaceuticals that mimic its effects, might serve as a geroprotective intervention, offering potential benefits for healthspan and longevity. The research underscores the importance of isoleucine in diet and aging, and its potential as a target for nutritional and pharmacological interventions in the field of gerontology.{{pmid|37939658}} | Isoleucine restriction (IleR) has been identified as a significant factor in improving metabolic health and extending lifespan, particularly in genetically heterogeneous UM-HET3 mice. Restricting dietary isoleucine by 67% promotes leanness and glycemic control in both sexes, while also reprogramming hepatic metabolism in a sex-specific manner. Notably, IleR has been observed to reduce frailty and increase the lifespan by 33% of both male and female mice, with more pronounced effects in males. These findings suggest that IleR, or pharmaceuticals that mimic its effects, might serve as a geroprotective intervention, offering potential benefits for healthspan and longevity. The research underscores the importance of isoleucine in diet and aging, and its potential as a target for nutritional and pharmacological interventions in the field of gerontology.{{pmid|37939658}} | ||