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 [[File:isoleucine Restriction in UM-HET3 mice.jpg|thumb|Isoleucine restriction in UM-HET3 mice<br>(Low ILE = Low isoleucine, Low AA = Low amino acid)]]
 === Isoleucine Restriction ===
-Isoleucine restriction (IleR) has been identified as a significant factor in improving metabolic health and extending lifespan, particularly in genetically heterogeneous mice. Restricting dietary isoleucine by 67% of 9-week-old UM-HET3 mice promotes leanness and glycemic control in both sexes, while also reprogramming hepatic metabolism in a sex-specific manner.
+Recent research has revealed that dietary isoleucine restriction (IleR) by 67% can have significant effects on metabolic health and lifespan, particularly in genetically heterogeneous UM-HET3 mice. Implemented in 9-week-old mice, IleR has been shown to promote leanness and improve glycemic control across genders. Additionally, it has been noted to cause sex-specific reprogramming of hepatic metabolism.{{pmid|37939658}}<ref>https://www.lifespan.io/news/isoleucine-restriction-boosts-lifespan-in-mice/</ref>
-Most importantly, isoleucine restriction led to a 33% percent increase in median lifespan and to some increase in maximum lifespan in male mice vs controls. This result is one of the most impressive for any intervention ever tested in rodents, especially in HET3 mice. For females, however, the increase in maximum lifespan was only 7%. In accordance with the lifespan results, male mice experienced significantly less frailty. Cancer is the cause of death in more than 80% of HET3 mice. Low Ile males were significantly less likely to get cancer during their lives, but Low Ile females were not.
+In male mice, a 33% increase in median lifespan was observed, along with a notable increase in maximum lifespan when compared to control groups. These findings are some of the most significant among interventions tested in rodent models. For female mice, the increase in maximum lifespan was more modest, at 7%. Correspondingly, male mice under IleR also experienced significantly reduced levels of frailty compared to their counterparts. The study also addresses mortality causes, indicating that while cancer accounts for the majority of deaths in HET3 mice, male mice on an IleR diet were considerably less likely to develop cancer, a benefit not as evident in female mice.
-These findings suggest that IleR, or pharmaceuticals that mimic its effects, might serve as a geroprotective intervention, offering potential benefits for healthspan and longevity. The research underscores the importance of isoleucine in diet and aging, and its potential as a target for nutritional and pharmacological interventions in the field of gerontology.{{pmid|37939658}}
+These findings suggest that isoleucine restriction, or pharmacological agents that replicate its effects, may offer a promising geroprotective strategy, potentially enhancing healthspan and longevity. Such findings underscore the significant role of isoleucine in diet and aging and point to its viability as a target for both nutritional and pharmacological interventions in gerontology.
 == See Also ==