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Isoleucine: Difference between revisions
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In male mice, a 33% increase in median lifespan was observed, along with a notable increase in maximum lifespan when compared to control groups. These findings are some of the most significant among interventions tested in rodent models. For female mice, the increase in maximum lifespan was more modest, at 7%. Correspondingly, male mice under IleR also experienced significantly reduced levels of frailty compared to their counterparts. The study also addresses mortality causes, indicating that while cancer accounts for the majority of deaths in HET3 mice, male mice on an IleR diet were considerably less likely to develop cancer, a benefit not as evident in female mice. | In male mice, a 33% increase in median lifespan was observed, along with a notable increase in maximum lifespan when compared to control groups. These findings are some of the most significant among interventions tested in rodent models. For female mice, the increase in maximum lifespan was more modest, at 7%. Correspondingly, male mice under IleR also experienced significantly reduced levels of frailty compared to their counterparts. The study also addresses mortality causes, indicating that while cancer accounts for the majority of deaths in HET3 mice, male mice on an IleR diet were considerably less likely to develop cancer, a benefit not as evident in female mice. | ||
These findings suggest that isoleucine restriction, or pharmacological agents that replicate its effects, may offer a promising [[ | These findings suggest that isoleucine restriction, or pharmacological agents that replicate its effects, may offer a promising [[Geroprotection|geroprotective]] strategy, potentially enhancing healthspan and longevity. Such findings underscore the significant role of isoleucine in diet and aging and point to its viability as a target for both nutritional and pharmacological interventions in gerontology. | ||
== See Also == | == See Also == | ||