Nematode Worms (Caenorhabditis Elegans): Difference between revisions

Nematode Worms (Caenorhabditis Elegans) (view source)

Revision as of 07:36, 8 December 2023

1,655 bytes removed , 8 December 2023

→‎Ageing

VisualWikitext

Strimo

Bureaucrats, Administrators

2,851

edits

@@ Line 36: / Line 36: @@
 ''C. elegans'' has been instrumental in the identification of the functions of genes implicated in Alzheimer's disease, such as presenilin.{{pmid|20012092}} Moreover, extensive research on ''C. elegans'' has identified RNA-binding proteins as essential factors during germline and early embryonic development.{{pmid|21402787}}
-Telomeres, the length of which have been shown to correlate with increased lifespan and delayed onset of [[Senecent Cells|senescence]] in a multitude of organisms, from ''C. elegans''<ref>{{Cite journal|last1=Coutts|first1=Fiona|last2=Palmos|first2=Alish B.|last3=Duarte|first3=Rodrigo R. R.|last4=de Jong|first4=Simone|last5=Lewis|first5=Cathryn M.|last6=Dima|first6=Danai|last7=Powell|first7=Timothy R.|date=March 2019|title=The polygenic nature of telomere length and the anti-ageing properties of lithium|journal=Neuropsychopharmacology|volume=44|issue=4|pages=757–765|doi=10.1038/s41386-018-0289-0|issn=1740-634X|pmc=6372618|pmid=30559463}}</ref><ref>{{Cite journal|last1=Raices|first1=Marcela|last2=Maruyama|first2=Hugo|last3=Dillin|first3=Andrew|last4=Karlseder|first4=Jan|date=September 2005|title=Uncoupling of longevity and telomere length in C. elegans|journal=PLOS Genetics|volume=1|issue=3|pages=e30|doi=10.1371/journal.pgen.0010030|issn=1553-7404|pmc=1200426|pmid=16151516 |doi-access=free }}</ref> to humans,<ref>{{Cite journal|last1=Lulkiewicz|first1=M.|last2=Bajsert|first2=J.|last3=Kopczynski|first3=P.|last4=Barczak|first4=W.|last5=Rubis|first5=B.|date=September 2020|title=Telomere length: how the length makes a difference|journal=Molecular Biology Reports|volume=47|issue=9|pages=7181–7188|doi=10.1007/s11033-020-05551-y|issn=1573-4978|pmc=7561533|pmid=32876842}}</ref> show an interesting behaviour in ''C. elegans.'' While ''C. elegans'' maintains its telomeres in a canonical way similar to other eukaryotes, in contrast ''[[Dros''
+Telomeres, the length of which have been shown to correlate with increased lifespan and delayed onset of [[Senecent Cells|senescence]] in a multitude of organisms, from ''C. elegans''{{pmid|30559463}}{{pmid|16151516}} to humans,{{pmid|32876842}} show an interesting behaviour in ''C. elegans.'' While ''C. elegans'' maintains its telomeres in a canonical way similar to other eukaryotes, in contrast ''[[Drosophila Melanogaster|Drosophila melanogaster]]'' is noteworthy in its use of retrotransposons to maintain its telomeres,{{pmid|21821789}} during knock-out of the catalytic subunit of the telomerase (''trt-1'') ''C. elegans'' can gain the ability of alternative telomere lengthening (ALT). ''C. elegans'' was the first eukaryote to gain ALT functionality after knock-out of the canonical telomerase pathway.{{pmid|16477310}} ALT is also observed in about 10-15% of all clinical cancers.{{pmid|20351727}} Thus ''C. elegans'' is a prime candidate for ALT research.{{pmid|27593554}}{{pmid|23390606}}{{pmid|27761361}} Bayat et al. showed the paradoxical shortening of telomeres during ''trt-1'' over-expression which lead to near sterility while the worms even exhibited a slight increase in lifespan, despite shortened telomeres.{{pmid|31954861}}
-[[Telomere]]s, the length of which have been shown to correlate with increased lifespan and delayed onset of [[senescence]] in a multitude of organisms, from ''C. elegans''{{pmid|30559463}}{{pmid|16151516}} to humans,{{pmid|32876842}} show an interesting behaviour in ''C. elegans.'' While ''C. elegans'' maintains its telomeres in a canonical way similar to other eukaryotes, in contrast ''[[Drosophila melanogaster]]'' is noteworthy in its use of [[retrotransposon]]s to maintain its telomeres,{{pmid|21821789}} during [[Gene knockout|knock-out]] of the [[Telomerase reverse transcriptase|catalytic subunit of the telomerase (''trt-1'')]] ''C. elegans'' can gain the ability of alternative telomere lengthening (ALT). ''C. elegans'' was the first eukaryote to gain ALT functionality after knock-out of the canonical [[telomerase]] pathway.{{pmid|16477310}} ALT is also observed in about 10-15% of all clinical cancers.{{pmid|20351727}} Thus ''C. elegans'' is a prime candidate for ALT research.{{pmid|27593554}}{{pmid|23390606}}{{pmid|27761361}} Bayat et al. showed the paradoxical shortening of telomeres during ''[[Telomerase reverse transcriptase|trt-1]]'' [[over-expression]] which lead to near [[Sterility (physiology)|sterility]] while the worms even exhibited a slight increase in lifespan, despite shortened telomeres.{{pmid|31954861}}
 ==See Also==
 *[[Model Organisms]]
-==References==
+==References ==
 <references />
 <references />
 [[Category:Model Organism]]