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Caloric Restriction: Difference between revisions
→Benefits of Caloric Restriction
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The NIA study on rhesus monkeys found no lifespan extension.{{pmid|22932268}} In a long-term study conducted at the ''Wisconsin National Primate Research Center'' over a period of 20 years on rhesus monkeys, a significantly better health status and a significantly increased lifespan were observed in the group of animals that received a reduced food supply during this period. In this group, 80% of the animals were still alive, compared to only 50% in the normally fed control group. Furthermore, in the animals with calorie restriction, a significantly delayed onset of age-associated diseases such as diabetes, cancer, and brain atrophy, as well as cardiovascular incidents, was observed. The authors of the study conclude that calorie restriction delays the aging process in this primate species.{{pmid|19590001}}<ref>rme: {{Webarchive |url=https://www.aerzteblatt.de/nachrichten/37311/Anti-Aging-Kalorienrestriktion-laesst-Affen-laenger-leben |title=Anti-Aging: Calorie Restriction Lets Monkeys Live Longer |wayback=20131015025849 |archive-bot=2019-09-14 14:53:42 InternetArchiveBot}} In: ''aerzteblatt.de'', July 10, 2009.</ref> | The NIA study on rhesus monkeys found no lifespan extension.{{pmid|22932268}} In a long-term study conducted at the ''Wisconsin National Primate Research Center'' over a period of 20 years on rhesus monkeys, a significantly better health status and a significantly increased lifespan were observed in the group of animals that received a reduced food supply during this period. In this group, 80% of the animals were still alive, compared to only 50% in the normally fed control group. Furthermore, in the animals with calorie restriction, a significantly delayed onset of age-associated diseases such as diabetes, cancer, and brain atrophy, as well as cardiovascular incidents, was observed. The authors of the study conclude that calorie restriction delays the aging process in this primate species.{{pmid|19590001}}<ref>rme: {{Webarchive |url=https://www.aerzteblatt.de/nachrichten/37311/Anti-Aging-Kalorienrestriktion-laesst-Affen-laenger-leben |title=Anti-Aging: Calorie Restriction Lets Monkeys Live Longer |wayback=20131015025849 |archive-bot=2019-09-14 14:53:42 InternetArchiveBot}} In: ''aerzteblatt.de'', July 10, 2009.</ref> | ||
== Mechanism == | |||
The reasons for the lifespan extension in model organisms through caloric restriction are not yet fully understood. The underlying mechanism of this effect remains unknown. It's possible that the extension of lifespan results from improved health status due to the absence of [[obesity]] and the delayed onset of age-related diseases of the [[Metabolic syndrome|metabolic syndrome]] such as [[Cardiovascular disease]]s and Type II [[Diabetes mellitus]]. | |||
Studies conducted with mice suggest that the lifespan extension associated with caloric restriction is not simply a result of leanness caused by calorie restriction. The maximum lifespan of male rats that maintained a low body fat mass through physical activity did not increase, but it did for mice that maintained a low body weight through caloric restriction alone, despite a sedentary lifestyle.{{pmid|17341713}} | |||
Caloric restriction in rats produces soluble factors in the blood serum that cause lifespan extension in human [[Cell culture]]s.{{pmid|25855056}} Various mechanisms are being discussed: | |||
==Benefits of Caloric Restriction== | ==Benefits of Caloric Restriction== | ||
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*Enhanced brain function and protection against neurodegenerative diseases | *Enhanced brain function and protection against neurodegenerative diseases | ||
*Possible extension of healthy lifespan | *Possible extension of healthy lifespan | ||
==Potential Risks and Concerns== | ==Potential Risks and Concerns== | ||
Caloric restriction, especially if not properly managed, can lead to: | Caloric restriction, especially if not properly managed, can lead to: | ||