2,851
edits
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
'''Calorie Restriction''' (CR), also known as '''calorie restriction''' or '''dietary restriction''', refers to a [[diet]] that reduces the intake of chemically bound [[energy]] from [[food]]s by 10 to 50 percent compared to ''[[ad libitum]]'' ("at will") [[nutrition]]. The goal is to achieve a higher [[life expectancy]] or at least delayed [[aging]] or health-promoting effects{{pmid|21663754}}{{pmid|19104499}}, without leading to [[malnutrition]]. | |||
In a number of [[model organism|model organisms]], a health-promoting and life-extending effect has been demonstrated through this method. However, no extension of life expectancy has been observed in some species or [[breed (breeding)|breeds]]. The extension of life expectancy in some rodent strains by up to 50%{{pmid|21840335}} is dependent on the [[genome]] and sex among other factors{{pmid|25269675}}. | |||
==Effects in Model Organisms== | ==Effects in Model Organisms== | ||
=== Positive Effects === | === Positive Effects === | ||
[[File:Caloric restriction 02.png|thumb|Effects of calorie restriction on the survival rate of laboratory mice (CR=Calorie Restriction).{{pmid|3958810}}]] | [[File:Caloric restriction 02.png|thumb|Effects of calorie restriction on the survival rate of laboratory mice (CR=Calorie Restriction).{{pmid|3958810}}]] |