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Caloric Restriction: Difference between revisions

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Caloric restriction (CR), a dietary regimen that reduces calorie intake without incurring malnutrition, has been a subject of scientific study in the context of aging and longevity. This practice is thought to extend lifespan and improve health outcomes in various species, including potentially humans.
'''Calorie Restriction''' (CR), also known as '''calorie restriction''' or '''dietary restriction''', refers to a [[diet]] that reduces the intake of chemically bound [[energy]] from [[food]]s by 10 to 50 percent compared to ''[[ad libitum]]'' ("at will") [[nutrition]]. The goal is to achieve a higher [[life expectancy]] or at least delayed [[aging]] or health-promoting effects{{pmid|21663754}}{{pmid|19104499}}, without leading to [[malnutrition]].
 
In a number of [[model organism|model organisms]], a health-promoting and life-extending effect has been demonstrated through this method. However, no extension of life expectancy has been observed in some species or [[breed (breeding)|breeds]]. The extension of life expectancy in some rodent strains by up to 50%{{pmid|21840335}} is dependent on the [[genome]] and sex among other factors{{pmid|25269675}}.
 
==Effects in Model Organisms==
==Effects in Model Organisms==
=== Positive Effects ===
=== Positive Effects ===
[[File:Caloric restriction 02.png|thumb|Effects of calorie restriction on the survival rate of laboratory mice (CR=Calorie Restriction).{{pmid|3958810}}]]
[[File:Caloric restriction 02.png|thumb|Effects of calorie restriction on the survival rate of laboratory mice (CR=Calorie Restriction).{{pmid|3958810}}]]
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