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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 20:36, 16 December 2023
, 16 December 2023→Controversy about NMN as Direct Precursor
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== Controversy about NMN as Direct Precursor == | == Controversy about NMN as Direct Precursor == | ||
[[File:Mean plasma concentration–time profiles of NAD+ and NR in mice following oral NMN administration.png|thumb|Mean plasma concentration–time profiles of nicotinamide adenine dinucleotide (NAD+) (A) and nicotinamide riboside (NR) (B) in mice following oral administration of NMN–HAP and free NMN{{pmid|37862582}}]] | |||
NMN is often advertised, for example by NMN suppliers, as a direct precursor to NAD+, purportedly making it more effective compared to other precursors like '''Nicotinamide Riboside (NR)'''. However, NMN's role as a direct precursor is only effective when it is '''inside the cell'''. This raises questions about how NMN, when ingested or administered externally, enters the cell to contribute to NAD+ synthesis. The central controversy surrounding NMN as a precursor to NAD+ lies in its mechanism of cellular entry. While NMN is a direct precursor of NAD+ within the cell, the debate focuses on whether NMN can be directly absorbed by cells or if it must first be converted to NR. In that case, NR might have an advantage over NMN, as NMN would require one additional conversion step compared to NR. | NMN is often advertised, for example by NMN suppliers, as a direct precursor to NAD+, purportedly making it more effective compared to other precursors like '''Nicotinamide Riboside (NR)'''. However, NMN's role as a direct precursor is only effective when it is '''inside the cell'''. This raises questions about how NMN, when ingested or administered externally, enters the cell to contribute to NAD+ synthesis. The central controversy surrounding NMN as a precursor to NAD+ lies in its mechanism of cellular entry. While NMN is a direct precursor of NAD+ within the cell, the debate focuses on whether NMN can be directly absorbed by cells or if it must first be converted to NR. In that case, NR might have an advantage over NMN, as NMN would require one additional conversion step compared to NR. | ||