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Nicotinamide Adenine Dinucleotide (NAD): Difference between revisions
Nicotinamide Adenine Dinucleotide (NAD) (view source)
Revision as of 00:59, 20 December 2023
, 20 December 2023→NAD+ and Circadian Rhythm
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SIRT1, a member of the sirtuin protein family involved in cellular response to stress, has been linked to longer life spans, though the results vary depending on the situation. For example, elite athletes, who have higher SIRT1 levels, tend to have longer telomeres (a sign of cellular aging) and are less likely to develop insulin resistance{{pmid|34256387}}. SIRT1 works by turning on certain genes, like FoxO and PGC1α, which are important for managing stress, controlling cell growth, and preventing tumors. These genes are known to contribute to longer lifespans in some animals{{pmid|26831453}}{{pmid|14976264}}{{pmid|16288288}}{{pmid|35004893}}. The IIS pathway, which influences growth, metabolism, and longevity, also promotes longer life under certain conditions by activating these genes{{pmid|26675724}}{{pmid|21443682}}. PGC1α, in particular, is key in creating mitochondria and has been linked to better insulin sensitivity in muscles{{pmid|23583953}}{{pmid|24559845}}{{pmid|23086035}}. Furthermore, AMPK, which is involved in energy management in the body, interacts with SIRT1 and can inhibit mTOR, another aging-related process. AMPK also helps increase NAD+ levels, thus boosting SIRT1 activity{{pmid|19262508}}. Additionally, SIRT1 can slow down NF-κB signaling, which is part of the immune response, helping to reduce long-term inflammation{{pmid|23770291}}. Having enough NAD+ to keep SIRT1 active is essential in manipulating the aging process and promoting longevity{{pmid|29883761}}{{pmid|33460497}}{{pmid|33609766}}{{pmid|32124104}}. Keeping NAD+ at healthy levels is key for making sure SIRT1 can do its job effectively as we age. | SIRT1, a member of the sirtuin protein family involved in cellular response to stress, has been linked to longer life spans, though the results vary depending on the situation. For example, elite athletes, who have higher SIRT1 levels, tend to have longer telomeres (a sign of cellular aging) and are less likely to develop insulin resistance{{pmid|34256387}}. SIRT1 works by turning on certain genes, like FoxO and PGC1α, which are important for managing stress, controlling cell growth, and preventing tumors. These genes are known to contribute to longer lifespans in some animals{{pmid|26831453}}{{pmid|14976264}}{{pmid|16288288}}{{pmid|35004893}}. The IIS pathway, which influences growth, metabolism, and longevity, also promotes longer life under certain conditions by activating these genes{{pmid|26675724}}{{pmid|21443682}}. PGC1α, in particular, is key in creating mitochondria and has been linked to better insulin sensitivity in muscles{{pmid|23583953}}{{pmid|24559845}}{{pmid|23086035}}. Furthermore, AMPK, which is involved in energy management in the body, interacts with SIRT1 and can inhibit mTOR, another aging-related process. AMPK also helps increase NAD+ levels, thus boosting SIRT1 activity{{pmid|19262508}}. Additionally, SIRT1 can slow down NF-κB signaling, which is part of the immune response, helping to reduce long-term inflammation{{pmid|23770291}}. Having enough NAD+ to keep SIRT1 active is essential in manipulating the aging process and promoting longevity{{pmid|29883761}}{{pmid|33460497}}{{pmid|33609766}}{{pmid|32124104}}. Keeping NAD+ at healthy levels is key for making sure SIRT1 can do its job effectively as we age. | ||
==NAD+ and | == NAD+ and Its Influence on the Body's Biological Clock == | ||
NAD+ plays | NAD+, a crucial molecule in our body, plays an important role in keeping our biological clock, or circadian rhythm, in check. Studies involving older mice have shown that when they have less NAD+, they experience more disruptions in their biological clock compared to younger mice with more NAD+{{pmid|32369735}}. This leads to problems in how their cells handle energy and time. By increasing NAD+ levels in mice with circadian rhythm issues, researchers have been able to fix these problems, particularly through the action of a protein called SIRT3{{pmid|24051248}}. Having enough NAD+ and ensuring that sirtuin proteins (like SIRT3) are active is key to keeping our internal clocks working properly. Taking supplements that increase NAD+ levels might help fix age-related issues with these biological clocks{{pmid|24657895}}. Low NAD+ levels are a common problem in many age-related diseases, so treatments that increase NAD+ are being researched as a way to help with these issues{{pmid|34743990}}{{pmid|31953124}}{{pmid|29295624}}{{pmid|34720589}}. | ||
== See also == | == See also == | ||
* [[NAD+ Booster]] | * [[NAD+ Booster]] | ||