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-{{Short description|Concentration of a compound where 50% of its maximal effect is observed}}
 {{DISPLAYTITLE:EC<sub>50</sub>}}
 [[File:Dose_response_antagonist.jpg|right|thumb|400px|The tissue response (y-axis) to an agonist, in log concentration (x-axis), in the presence of different antagonist concentrations. The EC<sub>50</sub> of the agonist is represented by the x co-ordinate that corresponds with the half-maximum of the leftmost curve. This is denoted by [A]]]
-'''Half maximal effective concentration''' ('''EC<sub>50</sub>''') is a measure of the concentration of a drug, antibody or toxicant which induces a [[stimulus–response model|biological response]] halfway between the baseline and maximum after a specified exposure time.<ref>{{cite web|url=http://www.graphpad.com/curvefit/introduction89.htm |title=Introducing dose response curves |archive-url=https://web.archive.org/web/20120730150339/http://www.graphpad.com/curvefit/introduction89.htm |archive-date=2012-07-30 |publisher=Graphpad Software}}</ref> More simply, EC<sub>50</sub> can be defined as the ''concentration required to obtain a 50% [...] effect''<ref>{{Cite journal |last1=Chen |first1=Zheng |last2=Bertin |first2=Riccardo |last3=Froldi |first3=Guglielmina |date=2013-05-01 |title=EC50 estimation of antioxidant activity in DPPH assay using several statistical programs |url=https://www.sciencedirect.com/science/article/pii/S0308814612016020 |journal=Food Chemistry |language=en |volume=138 |issue=1 |pages=414–420 |doi=10.1016/j.foodchem.2012.11.001 |pmid=23265506 |issn=0308-8146}}</ref> and may be also written as [A]<sub>50</sub>.<ref name = Terms>{{cite journal |title=International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology|url=https://www.guidetopharmacology.org/pdfs/termsAndSymbols.pdf|last1=Neubig|first1=Richard R.|journal=Pharmacological Reviews|year=2003|volume=55|issue=4|pages=597–606|doi=10.1124/pr.55.4.4|pmid=14657418|s2cid=1729572}}</ref> It is commonly used as a measure of a drug's [[Potency (pharmacology)|potency]], although the use of EC<sub>50</sub> is preferred over that of 'potency', which has been criticised for its vagueness.<ref name = Terms/> EC<sub>50</sub> is a measure of concentration, expressed in [[Molar concentration|molar units]] (M), where 1&nbsp;M is equivalent to 1&nbsp;[[Mole (unit)|mol]]/[[Liter|L]].
+'''Half maximal effective concentration''' ('''EC<sub>50</sub>''') is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time.<ref>{{cite web|url=http://www.graphpad.com/curvefit/introduction89.htm |title=Introducing dose response curves |archive-url=https://web.archive.org/web/20120730150339/http://www.graphpad.com/curvefit/introduction89.htm |archive-date=2012-07-30 |publisher=Graphpad Software}}</ref> More simply, EC<sub>50</sub> can be defined as the ''concentration required to obtain a 50% [...] effect''<ref>{{Cite journal |last1=Chen |first1=Zheng |last2=Bertin |first2=Riccardo |last3=Froldi |first3=Guglielmina |date=2013-05-01 |title=EC50 estimation of antioxidant activity in DPPH assay using several statistical programs |url=https://www.sciencedirect.com/science/article/pii/S0308814612016020 |journal=Food Chemistry |language=en |volume=138 |issue=1 |pages=414–420 |doi=10.1016/j.foodchem.2012.11.001 |pmid=23265506 |issn=0308-8146}}</ref> and may be also written as [A]<sub>50</sub>.<ref name = Terms>{{cite journal |title=International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology|url=https://www.guidetopharmacology.org/pdfs/termsAndSymbols.pdf|last1=Neubig|first1=Richard R.|journal=Pharmacological Reviews|year=2003|volume=55|issue=4|pages=597–606|doi=10.1124/pr.55.4.4|pmid=14657418|s2cid=1729572}}</ref> It is commonly used as a measure of a drug's potency, although the use of EC<sub>50</sub> is preferred over that of 'potency', which has been criticised for its vagueness.<ref name = Terms/> EC<sub>50</sub> is a measure of concentration, expressed in molar units (M), where 1&nbsp;M is equivalent to 1&nbsp;mol/L.
-The EC<sub>50</sub> of a ''graded'' [[dose response curve]] therefore represents the concentration of a compound where 50% of its maximal effect is observed.<ref>{{cite web|url=http://www.biochem.northwestern.edu/holmgren/Glossary/Definitions/Def-E/EC50.html|title=Northwestern Molbiosci EC50 definition|access-date=2019-05-27}}</ref>
+The EC<sub>50</sub> of a ''graded'' dose response curve therefore represents the concentration of a compound where 50% of its maximal effect is observed.<ref>{{cite web|url=http://www.biochem.northwestern.edu/holmgren/Glossary/Definitions/Def-E/EC50.html|title=Northwestern Molbiosci EC50 definition|access-date=2019-05-27}}</ref>
 The EC<sub>50</sub> of a ''quantal'' dose response curve represents the concentration of a compound where 50% of the population exhibit a response,<ref>{{Cite web |url=http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm%2Fbc%2F190116.htm |title=Drug Dose and Clinical Response	 |access-date=2019-04-16 |archive-url=https://web.archive.org/web/20070220004824/http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm%2Fbc%2F190116.htm |archive-date=2007-02-20 |url-status=dead }}</ref> after a specified exposure duration.
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 * [[IC50|IC<sub>50</sub>]]
+* {{SeeWikipedia|EC50}}
 == References ==
 <references />