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SIRT6: Difference between revisions
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== Modulator Compounds == | |||
=== Activating Compounds === | |||
{| class="wikitable" | {| class="wikitable" | ||
! colspan="1" rowspan="1" |Compound | |||
! colspan="1" rowspan="1" |[[EC50|EC<sub>50</sub>]] value (µM) | |||
! colspan="1" rowspan="1" |Maximal activation (fold) | |||
|- | |- | ||
| colspan="1" rowspan="1" |Luteolin | | colspan="1" rowspan="1" |Luteolin | ||
| Line 12: | Line 15: | ||
| colspan="1" rowspan="1" |3.0 | | colspan="1" rowspan="1" |3.0 | ||
|- | |- | ||
| colspan="1" rowspan="1" |Quercetin | | colspan="1" rowspan="1" |[[Quercetin]] | ||
| colspan="1" rowspan="1" |990 ± 250 | | colspan="1" rowspan="1" |990 ± 250 | ||
| colspan="1" rowspan="1" |10 | | colspan="1" rowspan="1" |10 | ||
| Line 27: | Line 30: | ||
| colspan="1" rowspan="1" |760 ± 200 | | colspan="1" rowspan="1" |760 ± 200 | ||
| colspan="1" rowspan="1" |6.3 | | colspan="1" rowspan="1" |6.3 | ||
|} | |||
=== Inhibiting Compounds === | |||
{| class="wikitable" | |||
! colspan="1" rowspan="1" |Compound | |||
! colspan="2" rowspan="1" |[[IC50|IC<sub>50</sub>]] value (µM) | |||
|- | |||
| colspan="1" rowspan="1" |(−)-Catechin gallate | |||
| colspan="2" rowspan="1" |2.5 ± 0.03 | |||
|- | |||
| colspan="1" rowspan="1" |(−)-Gallocatechin gallate | |||
| colspan="2" rowspan="1" |5.4 ± 0.04 | |||
|} | |} | ||