Hallmarks of Aging: Difference between revisions

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-Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The '''hallmarks of aging''' are the types of [[Biochemistry|biochemical]] changes that occur in all organisms that experience [[Senescence|biological aging]] and lead to a progressive loss of physiological integrity, impaired function and, eventually, [[Death|death]]. They were first listed in a landmark paper in 2013<ref name=":0" /> to conceptualize the essence of [[Senescence|biological aging]] and its underlying mechanisms.
+Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The '''hallmarks of aging''' are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013<ref name=":0" /> to conceptualize the essence of biological aging and its underlying mechanisms.
 == Criteria ==
-Each hallmark was chosen to try to fulfill the following criteria:<ref name=":02">{{Cite journal|last1=López-Otín|title=The Hallmarks of Aging|pmc=3836174|issn=0092-8674|doi=10.1016/j.cell.2013.05.039|pages=1194–1217|issue=6|volume=153|journal=Cell|url=http://dx.doi.org/10.1016/j.cell.2013.05.039|date=2013-06-06|first1=Carlos|first5=Guido|last5=Kroemer|first4=Manuel|last4=Serrano|first3=Linda|last3=Partridge|first2=Maria A.|last2=Blasco|pmid=23746838}}</ref>
+Each hallmark was chosen to try to fulfill the following criteria:<ref name=":0" />
 # manifests during normal aging;