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Hallmarks of Aging: Difference between revisions
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These conditions are met to different extents by each of these hallmarks. The last criterion is not present in many of the hallmarks, as science has not yet found feasible ways to amend these problems in living organisms. | These conditions are met to different extents by each of these hallmarks. The last criterion is not present in many of the hallmarks, as science has not yet found feasible ways to amend these problems in living organisms. | ||
== Overview == | |||
{| class="wikitable" | |||
! Hallmark | |||
! Description | |||
|- | |||
| Genomic Instability | |||
| Accumulation of DNA damage over time leading to cellular dysfunction. | |||
|- | |||
| Telomere Attrition | |||
| Reduction in the length of telomeres leading to cellular aging. | |||
|- | |||
| Epigenetic Alterations | |||
| Changes in DNA methylation and histone modification affecting gene expression. | |||
|- | |||
| Loss of Proteostasis | |||
| Disruption in protein folding and stability leading to cell damage. | |||
|- | |||
| Deregulated Nutrient Sensing | |||
| Alterations in nutrient sensing pathways affecting metabolism and aging. | |||
|- | |||
| Mitochondrial Dysfunction | |||
| Decrease in mitochondrial efficiency and increase in oxidative stress. | |||
|- | |||
| Cellular Senescence | |||
| Accumulation of non-dividing, dysfunctional cells secreting harmful factors. | |||
|- | |||
| Stem Cell Exhaustion | |||
| Decline in the regenerative capacity of stem cells affecting tissue repair. | |||
|- | |||
| Altered Intercellular Communication | |||
| Changes in cellular communication leading to inflammation and tissue dysfunction. | |||
|} | |||
== History == | == History == | ||